loading...| Preferred Name | kernicterus | |
| Synonyms |
bilirubin-induced encephalopathy bilirubin-induced neurologic dysfunction kemicterus BIND Bilirubin encephalopathy |
|
| Definitions |
A term used pathologically to describe bilirubin staining of the basal ganglia; brain stem; and cerebellum and clinically to describe a syndrome associated with HYPERbilirubinEMIA. Clinical features include athetosis, muscle spasticity or hypotonia, impaired vertical gaze, and deafness. Nonconjugated bilirubin enters the brain and acts as a neurotoxin, often in association with conditions that impair the blood-brain barrier (e.g., sepsis). This condition occurs primarily in neonates (infant, newborn), but may rarely occur in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613) [MeSH] |
|
| ID |
http://www.radlex.org/RID/RID5059 |
|
| Definition |
A term used pathologically to describe bilirubin staining of the basal ganglia; brain stem; and cerebellum and clinically to describe a syndrome associated with HYPERbilirubinEMIA. Clinical features include athetosis, muscle spasticity or hypotonia, impaired vertical gaze, and deafness. Nonconjugated bilirubin enters the brain and acts as a neurotoxin, often in association with conditions that impair the blood-brain barrier (e.g., sepsis). This condition occurs primarily in neonates (infant, newborn), but may rarely occur in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613) [MeSH] |
|
| label |
RID5059 |
|
| Preferred_name |
kernicterus |
|
| prefixIRI |
RID1:RID5059 |
|
| prefLabel |
kernicterus |
|
| Synonym |
bilirubin-induced encephalopathy bilirubin-induced neurologic dysfunction kemicterus BIND Bilirubin encephalopathy |
|
| UMLS_ID |
C0022610 |
|
| subClassOf |