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Pathway Ontology
Last uploaded:
October 21, 2024
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| Preferred Name | tumor necrosis factor mediated signaling pathway | |
| Synonyms |
TNF signaling pathway tumor necrosis factor-mediated signaling pathway TNF signaling TNFalpha signaling pathway |
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| Definitions |
Tumor necrosis factor (Tnf) signaling plays pivotal roles in immunity, cell proliferation, differentiation and apoptosis by activating several pathways. NF-kB is a major pathway activated by Tnf; others include JNK and P38 MAPK. Through receptor-associated adapters, Tnf elicits apoptosis via the extrinsic pathway. Deregulation of Tnf signaling has been implicated in a great number of human diseases - cerebral malaria, cancer and multiple sclerosis are a few examples. |
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| ID |
http://purl.obolibrary.org/obo/PW_0000233 |
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| definition |
Tumor necrosis factor (Tnf) signaling plays pivotal roles in immunity, cell proliferation, differentiation and apoptosis by activating several pathways. NF-kB is a major pathway activated by Tnf; others include JNK and P38 MAPK. Through receptor-associated adapters, Tnf elicits apoptosis via the extrinsic pathway. Deregulation of Tnf signaling has been implicated in a great number of human diseases - cerebral malaria, cancer and multiple sclerosis are a few examples.
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| has_obo_namespace |
pathway
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| has_related_synonym |
TNF signaling pathway tumor necrosis factor-mediated signaling pathway TNF signaling TNFalpha signaling pathway
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|
| id |
PW:0000233
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| label |
tumor necrosis factor mediated signaling pathway
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| notation |
PW:0000233
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| prefLabel |
tumor necrosis factor mediated signaling pathway
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| treeView |
http://purl.obolibrary.org/obo/PW_0000926 |
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| subClassOf |
http://purl.obolibrary.org/obo/PW_0000926 |
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