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PMO Precision Medicine Ontology
Last uploaded:
December 16, 2020
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| Preferred Name | Intracellular Signal Transduction | |
| Synonyms |
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| Definitions |
"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] |
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| ID |
http://www.phoc.org.cn/pmo/class/PMO_00064230 |
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| Database_Cross_Reference |
GO:0035556
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| Definition |
"The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell." [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
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| Gene Annotation |
ECT2(UniProtKB:Q9H8V3) MAPKAPK3(UniProtKB:Q16644) RP1L1(UniProtKB:Q8IWN7) ASB6(UniProtKB:Q9NWX5) MAP4K5(UniProtKB:Q9Y4K4) MAPK6(UniProtKB:Q16659) STK4(UniProtKB:Q13043) SDCBP(UniProtKB:O00560) MAPK7(UniProtKB:Q13164) LCP2(UniProtKB:Q13094) NLRC3(UniProtKB:Q7RTR2) BLK(UniProtKB:P51451) CIT(UniProtKB:O14578) CDC42BPA(UniProtKB:Q5VT25) PATJ(UniProtKB:Q8NI35) NUDT4(UniProtKB:Q9NZJ9) TYK2(UniProtKB:P29597) NFATC1(UniProtKB:O95644) NSMCE1(UniProtKB:Q8WV22) MAST2(UniProtKB:Q6P0Q8) RASSF5(UniProtKB:Q8WWW0) PRKAR2A(UniProtKB:P13861) CISH(UniProtKB:Q9NSE2) FKBP8(UniProtKB:Q14318) SIPA1(UniProtKB:Q96FS4) STMN1(UniProtKB:P16949) SMAD4(UniProtKB:Q13485) SPSB2(UniProtKB:Q99619) ARHGEF2(UniProtKB:Q92974) LEP(UniProtKB:P41159) AGTR2(UniProtKB:P50052) PAG1(UniProtKB:Q9NWQ8) HUNK(UniProtKB:P57058) NRG1(UniProtKB:Q02297) RACGAP1(UniProtKB:Q9H0H5) SMAD2(UniProtKB:Q15796) DGKZ(UniProtKB:Q13574) PLCL1(UniProtKB:Q15111) NOD2(UniProtKB:Q9HC29) SHC4(UniProtKB:Q6S5L8) H0Y980(UniProtKB:H0Y980) RASA4B(UniProtKB:C9J798) TEC(UniProtKB:P42680) PLXNB1(UniProtKB:O43157) PPP1R1C(UniProtKB:Q8WVI7) ITK(UniProtKB:Q08881) PRKCG(UniProtKB:P05129) NLRC5(UniProtKB:Q86WI3) BTK(UniProtKB:Q06187) H0YJX3(UniProtKB:H0YJX3) MYZAP(UniProtKB:P0CAP1) DVL1(UniProtKB:O14640) TLK1(UniProtKB:Q9UKI8) DGKB(UniProtKB:Q9Y6T7) LAX1(UniProtKB:Q8IWV1) MAPK15(UniProtKB:Q8TD08) DGKK(UniProtKB:Q5KSL6) PRKCQ(UniProtKB:Q04759) RAC1(UniProtKB:P63000) DLG5(UniProtKB:Q8TDM6) ASB15(UniProtKB:Q8WXK1) WSB1(UniProtKB:Q9Y6I7) CAMK4(UniProtKB:Q16566) LRRK2(UniProtKB:Q5S007) PRKAG2(UniProtKB:Q9UGJ0) MAPK13(UniProtKB:O15264) JAK1(UniProtKB:P23458) MAP4K4(UniProtKB:O95819) LAT(UniProtKB:O43561) ADRA1A(UniProtKB:P35348) SGK2(UniProtKB:Q9HBY8) CD80(UniProtKB:P33681) CAB39(UniProtKB:Q9Y376) CRKL(UniProtKB:P46109) MARK3(UniProtKB:P27448) PDPK1(UniProtKB:O15530) DCDC2C(UniProtKB:A8MYV0) PRKCB(UniProtKB:P05771) RPS6KA5(UniProtKB:O75582) BLNK(UniProtKB:Q8WV28) CXCL8(UniProtKB:P10145) DEPTOR(UniProtKB:Q8TB45) AKT2(UniProtKB:P31751) STK38(UniProtKB:Q15208) MAP3K3(UniProtKB:Q99759) TSSK3(UniProtKB:Q96PN8) RAC3(UniProtKB:P60763) SOCS1(UniProtKB:O15524) POLR2M(UniProtKB:P0CAP2) ASB7(UniProtKB:Q9H672) DAPK2(UniProtKB:Q9UIK4) TSSK2(UniProtKB:Q96PF2) BRSK2(UniProtKB:Q8IWQ3) GMIP(UniProtKB:Q9P107) EFS(UniProtKB:O43281) PPP1R1B(UniProtKB:Q9UD71) CAPS(UniProtKB:Q13938) UNC13A(UniProtKB:Q9UPW8) PDPK2P(UniProtKB:Q6A1A2) STK3(UniProtKB:Q13188) SCG2(UniProtKB:P13521) PASK(UniProtKB:Q96RG2) TGFBR3(UniProtKB:Q03167) SPSB4(UniProtKB:Q96A44) IRAK2(UniProtKB:O43187) MAPK10(UniProtKB:P53779) MCF2(UniProtKB:P10911) PRKAA2(UniProtKB:P54646) NRG3(UniProtKB:P56975) TOLLIP(UniProtKB:Q9H0E2) RGS11(UniProtKB:O94810) SIK1(UniProtKB:P57059) CHN2(UniProtKB:A0A2R8YEI5) JAK2(UniProtKB:O60674) ZBTB33(UniProtKB:Q86T24) ASB8(UniProtKB:Q9H765) DAPK1(UniProtKB:P53355) MELK(UniProtKB:Q14680) ASB13(UniProtKB:Q8WXK3) PLCL2(UniProtKB:Q9UPR0) ASB14(UniProtKB:A6NK59) LATS2(UniProtKB:Q9NRM7) NRG2(UniProtKB:O14511) SIK1B(UniProtKB:A0A0B4J2F2) PLCZ1(UniProtKB:Q86YW0) DEF8(UniProtKB:Q6ZN54) CD209(UniProtKB:Q9NNX6) DCDC1(UniProtKB:M0R2J8) IRAK3(UniProtKB:Q9Y616) RGS9(UniProtKB:O75916) SH3BP5(UniProtKB:O60239) PKN1(UniProtKB:Q16512) NUAK2(UniProtKB:Q9H093) HASPIN(UniProtKB:Q8TF76) PSEN2(UniProtKB:P49810) DVL1P1(UniProtKB:P54792) DEPDC5(UniProtKB:O75140) STK38L(UniProtKB:Q9Y2H1) GPR155(UniProtKB:Q7Z3F1) DAPK3(UniProtKB:O43293) MAP4K3(UniProtKB:Q8IVH8) IGFBP5(UniProtKB:P24593) NIM1K(UniProtKB:Q8IY84) DVL3(UniProtKB:Q92997) SRPK1(UniProtKB:Q96SB4) DGKH(UniProtKB:Q86XP1) BRSK1(UniProtKB:Q8TDC3) PLCB4(UniProtKB:Q15147) MCF2L(UniProtKB:O15068) PLA2G4C(UniProtKB:Q9UP65) PREX1(UniProtKB:Q8TCU6) MAPK9(UniProtKB:P45984) PLCD4(UniProtKB:Q9BRC7) FYN(UniProtKB:P06241) RPS6KA3(UniProtKB:P51812) NRBP2(UniProtKB:Q9NSY0) MAPKAPK5(UniProtKB:Q8IW41) NUAK1(UniProtKB:O60285) SH3BP5L(UniProtKB:Q7L8J4) SS18(UniProtKB:Q15532) MAPK12(UniProtKB:P53778) RALGPS1(UniProtKB:Q5JS13) ASB4(UniProtKB:Q9Y574) NOD1(UniProtKB:Q9Y239) CSPG4(UniProtKB:Q6UVK1) PRKAA1(UniProtKB:Q13131) RPS6KA4(UniProtKB:O75676) DCX(UniProtKB:O43602) ASB16(UniProtKB:Q96NS5) STK32C(UniProtKB:Q86UX6) PLCD3(UniProtKB:Q8N3E9) STAC(UniProtKB:Q99469) PDZD8(UniProtKB:Q8NEN9) PRKCA(UniProtKB:P17252) DCDC2B(UniProtKB:A2VCK2) ASB1(UniProtKB:Q9Y576) RGS7(UniProtKB:P49802) MASTL(UniProtKB:Q96GX5) GRIP1(UniProtKB:Q9Y3R0) TIAM2(UniProtKB:Q8IVF5) ASB9(UniProtKB:Q96DX5) TLK2(UniProtKB:Q86UE8) PPP1R1A(UniProtKB:Q13522) SIK2(UniProtKB:Q9H0K1) PPP1R17(UniProtKB:O96001) UNC13B(UniProtKB:O14795) ARFGEF2(UniProtKB:Q9Y6D5) MAPK3(UniProtKB:P27361) PLA2G1B(UniProtKB:P04054) DEDD2(UniProtKB:Q8WXF8) WNK4(UniProtKB:Q96J92) DEPDC7(UniProtKB:Q96QD5) PLEKHM1(UniProtKB:Q9Y4G2) PRKCE(UniProtKB:Q02156) JAK3(UniProtKB:P52333) GUCY1A2(UniProtKB:P33402) DGKE(UniProtKB:P52429) SIK3(UniProtKB:Q9Y2K2) BMX(UniProtKB:P51813) TRAF3IP2(UniProtKB:O43734) MAK(UniProtKB:P20794) STK39(UniProtKB:Q9UEW8) CD200R1(UniProtKB:Q8TD46) GCOM2(UniProtKB:Q9BZD3) ASB18(UniProtKB:Q6ZVZ8) TSSK4(UniProtKB:Q6SA08) PRKD2(UniProtKB:Q9BZL6) SMPD2(UniProtKB:O60906) SH2B3(UniProtKB:Q9UQQ2) CCDC68(UniProtKB:Q9H2F9) MARK1(UniProtKB:Q9P0L2) PIKFYVE(UniProtKB:Q9Y2I7) ITGB1BP1(UniProtKB:O14713) SRPK3(UniProtKB:Q9UPE1) TNS2(UniProtKB:Q63HR2) DDX3X(UniProtKB:O00571) CHEK1(UniProtKB:O14757) NET1(UniProtKB:Q7Z628) CHN2(UniProtKB:P52757) ARHGEF28(UniProtKB:Q8N1W1) CLNK(UniProtKB:Q7Z7G1) CHN1(UniProtKB:P15882) DGKI(UniProtKB:O75912) MAPK4(UniProtKB:P31152) RAPGEF2(UniProtKB:Q9Y4G8) RASA1(UniProtKB:P20936) CDC42BPB(UniProtKB:Q9Y5S2) MAP3K4(UniProtKB:Q9Y6R4) AKAP11(UniProtKB:Q9UKA4) PRKCH(UniProtKB:P24723) MAPK8(UniProtKB:P45983) PSEN1(UniProtKB:P49768) PRKCD(UniProtKB:Q05655) FMN2(UniProtKB:Q9NZ56) DGKA(UniProtKB:P23743) ASB11(UniProtKB:Q8WXH4) PRKD1(UniProtKB:Q15139) INPP5D(UniProtKB:Q92835) APBB2(UniProtKB:Q92870) WSB2(UniProtKB:Q9NYS7) GCOM1(UniProtKB:H8Y6P7) SQSTM1(UniProtKB:Q13501) AKT3(UniProtKB:Q9Y243) RPS6KA2(UniProtKB:Q15349) GUCY2D(UniProtKB:Q02846) PLEK2(UniProtKB:Q9NYT0) PTPN6(UniProtKB:P29350) TGFBR1(UniProtKB:P36897) NLK(UniProtKB:Q9UBE8) DCLK1(UniProtKB:O15075) OXSR1(UniProtKB:O95747) HSPB1(UniProtKB:P04792) CARHSP1(UniProtKB:Q9Y2V2) SOCS3(UniProtKB:O14543) ASB3(UniProtKB:Q9Y575) RPS6KB1(UniProtKB:P23443) SIRPG(UniProtKB:Q9P1W8) RP1(UniProtKB:P56715) NRG4(UniProtKB:Q8WWG1) TYROBP(UniProtKB:O43914) TREM1(UniProtKB:Q9NP99) DEPDC1(UniProtKB:Q5TB30) ADCY10(UniProtKB:Q96PN6) ARHGEF4(UniProtKB:Q9NR80) CTGF(UniProtKB:P29279) MLXIPL(UniProtKB:Q9NP71) ARHGEF7(UniProtKB:Q14155) SH2D6(UniProtKB:Q7Z4S9) SNRK(UniProtKB:Q9NRH2) SOCS2(UniProtKB:O14508) SDCBP2(UniProtKB:Q9H190) DGKG(UniProtKB:P49619) PKN2(UniProtKB:Q16513) IRAK1(UniProtKB:P51617) MAST4(UniProtKB:O15021) GSK3B(UniProtKB:P49841) HCLS1(UniProtKB:P14317) KALRN(UniProtKB:O60229) PINK1(UniProtKB:Q9BXM7) DGKD(UniProtKB:Q16760) MYO9A(UniProtKB:B2RTY4) AKT1(UniProtKB:P31749) SRPK2(UniProtKB:P78362) ARHGEF5(UniProtKB:Q12774) NLRX1(UniProtKB:Q86UT6) DUSP1(UniProtKB:P28562) DCDC2(UniProtKB:Q9UHG0) PRKAR2B(UniProtKB:P31323) PRKCZ(UniProtKB:Q05513) HMOX1(UniProtKB:P09601) WNK1(UniProtKB:Q9H4A3) PRKCSH(UniProtKB:P14314) MAPK14(UniProtKB:Q16539) CAMKK1(UniProtKB:Q8N5S9) ANP32A(UniProtKB:P39687) MARK4(UniProtKB:Q96L34) STAC2(UniProtKB:Q6ZMT1) WNK3(UniProtKB:Q9BYP7) ASB10(UniProtKB:Q8WXI3) MKNK1(UniProtKB:Q9BUB5) STYXL1(UniProtKB:Q9Y6J8) WNK2(UniProtKB:Q9Y3S1) MC1R(UniProtKB:Q01726) MARK2(UniProtKB:Q7KZI7) TSSK1B(UniProtKB:Q9BXA7) DEPDC4(UniProtKB:Q8N2C3) MAST3(UniProtKB:O60307) NFAM1(UniProtKB:Q8NET5) DNMBP(UniProtKB:Q6XZF7) PRKAG3(UniProtKB:Q9UGI9) STK32B(UniProtKB:Q9NY57) SGK3(UniProtKB:Q96BR1) YWHAE(UniProtKB:P62258) NRBP1(UniProtKB:Q9UHY1) LATS1(UniProtKB:O95835) SOCS5(UniProtKB:O75159) TUFT1(UniProtKB:Q9NNX1) DCLK2(UniProtKB:Q8N568) MAPKAPK2(UniProtKB:P49137) LOC112268381(UniProtKB:A0A2R8YFR7) SOCS7(UniProtKB:O14512) TP53TG5(UniProtKB:Q9Y2B4) ASB17(UniProtKB:Q8WXJ9) STAC3(UniProtKB:Q96MF2) SH2B1(UniProtKB:Q9NRF2) ARHGAP45(UniProtKB:Q92619) PLCD1(UniProtKB:P51178) NEURL2(UniProtKB:Q9BR09) MAST1(UniProtKB:Q9Y2H9) CORO2A(UniProtKB:Q92828) ADRA1B(UniProtKB:P35368) MAPK11(UniProtKB:Q15759) PRKAR1A(UniProtKB:P10644) ASB2(UniProtKB:Q96Q27) RPS6KA1(UniProtKB:Q15418) ACOT11(UniProtKB:Q8WXI4) LYN(UniProtKB:P07948) ZAP70(UniProtKB:P43403) MKNK2(UniProtKB:Q9HBH9) STK17B(UniProtKB:O94768) MAP4K2(UniProtKB:Q12851) RPS6KB2(UniProtKB:Q9UBS0) SH2B2(UniProtKB:O14492) TNIK(UniProtKB:Q9UKE5) GPR75-ASB3(UniProtKB:A0A0A6YYF3) CLEC4M(UniProtKB:Q9H2X3) STK32A(UniProtKB:Q8WU08) RGS14(UniProtKB:O43566) S100A1(UniProtKB:P23297) ERBB2(UniProtKB:P04626) STK17A(UniProtKB:Q9UEE5) NEK11(UniProtKB:Q8NG66) CDC42BPG(UniProtKB:Q6DT37) MOK(UniProtKB:Q9UQ07) MAP3K12(UniProtKB:Q12852) DEPDC1B(UniProtKB:Q8WUY9) RIT2(UniProtKB:Q99578) TGFA(UniProtKB:P01135) MAGI3(UniProtKB:Q5TCQ9) GUCY2C(UniProtKB:P25092) GNB1L(UniProtKB:Q9BYB4) PRKCI(UniProtKB:P41743) PKN3(UniProtKB:Q6P5Z2) CXCL1(UniProtKB:P09341) TSSK6(UniProtKB:Q9BXA6) DMRT1(UniProtKB:Q9Y5R6) ICK(UniProtKB:Q9UPZ9) SOCS6(UniProtKB:O14544) SPHK1(UniProtKB:Q9NYA1) RGS6(UniProtKB:P49758) IRAK4(UniProtKB:Q9NWZ3) SOCS4(UniProtKB:Q8WXH5) ASB5(UniProtKB:Q8WWX0) LAT2(UniProtKB:Q9GZY6) DMPK(UniProtKB:Q09013) MAPK1(UniProtKB:P28482) KCTD9(UniProtKB:Q7L273) SRC(UniProtKB:P12931) UNC13C(UniProtKB:Q8NB66) DGKQ(UniProtKB:P52824) SGK1(UniProtKB:O00141) FER(UniProtKB:P16591)
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| label |
Intracellular Signal Transduction
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| MCID |
MC04799822
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| PMOID |
PMO:00064230
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| prefixIRI |
pmo:PMO_00064230
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| prefLabel |
Intracellular Signal Transduction
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| Synonym |
"intracellular signal transduction pathway" NARROW [] "intracellular signaling cascade" RELATED [GOC:signaling] "protein kinase cascade" NARROW [GOC:signaling] "signal transduction via intracellular signaling cascade" RELATED [] "intracellular signaling pathway" RELATED [] "signal transmission via intracellular cascade" NARROW [] "intracellular signaling chain" EXACT [ISBN:3527303782] "intracellular protein kinase cascade" NARROW [GOC:signaling]
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| Tree Number |
T10.1.29.20.39 T10.1.26.1.33.23.39
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| subClassOf |
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