PMO Precision Medicine Ontology

Last uploaded: December 16, 2020
Preferred Name

Signal Transduction
Synonyms
Definitions

"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]

ID

http://www.phoc.org.cn/pmo/class/PMO_00063723

Database_Cross_Reference

GO:0007165

Definition

"The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11]

Gene Annotation

CD53(UniProtKB:P19397)

P2RX4(UniProtKB:Q99571)

MAPKAPK3(UniProtKB:Q16644)

TXNRD1(UniProtKB:Q16881)

CD33(UniProtKB:P20138)

OPN1LW(UniProtKB:P04000)

KIT(UniProtKB:P10721)

RSU1(UniProtKB:Q15404)

COPS2(UniProtKB:P61201)

CCL11(UniProtKB:P51671)

CAMLG(UniProtKB:P49069)

MAPK6(UniProtKB:Q16659)

STK4(UniProtKB:Q13043)

SUFU(UniProtKB:Q9UMX1)

IFNGR1(UniProtKB:P15260)

LRRD1(UniProtKB:A4D1F6)

MAPK7(UniProtKB:Q13164)

EPOR(UniProtKB:P19235)

ULK2(UniProtKB:Q8IYT8)

RASSF10(UniProtKB:A6NK89)

RERGL(UniProtKB:Q9H628)

TMIGD3(UniProtKB:P0DMS9)

RCVRN(UniProtKB:P35243)

ANK3(UniProtKB:Q12955)

NLRP12(UniProtKB:P59046)

CHRNB1(UniProtKB:P11230)

KLRK1(UniProtKB:P26718)

MAP2K6(UniProtKB:P52564)

SKAP2(UniProtKB:O75563)

PPARG(UniProtKB:P37231)

HINT1(UniProtKB:P49773)

OR3A2(UniProtKB:P47893)

HDGFL3(UniProtKB:Q9Y3E1)

TNFRSF8(UniProtKB:P28908)

MAP2K4(UniProtKB:P45985)

FGF9(UniProtKB:P31371)

RASSF6(UniProtKB:Q6ZTQ3)

IGF1(UniProtKB:P05019)

SARM1(UniProtKB:Q6SZW1)

VDR(UniProtKB:P11473)

ARHGAP39(UniProtKB:Q9C0H5)

PDE9A(UniProtKB:O76083)

F2RL3(UniProtKB:Q96RI0)

HBEGF(UniProtKB:Q99075)

CEACAM6(UniProtKB:P40199)

ENDOU(UniProtKB:P21128)

CNIH1(UniProtKB:O95406)

GPI(UniProtKB:P06744)

ARTN(UniProtKB:Q5T4W7)

PLCXD2(UniProtKB:Q0VAA5)

METRN(UniProtKB:Q9UJH8)

SCGB3A1(UniProtKB:Q96QR1)

REG1A(UniProtKB:P05451)

RPS6KA6(UniProtKB:Q9UK32)

SECTM1(UniProtKB:Q8WVN6)

FGF17(UniProtKB:O60258)

OMP(UniProtKB:P47874)

CRABP1(UniProtKB:P29762)

RANBP1(UniProtKB:P43487)

SOS1(UniProtKB:Q07889)

NR1I2(UniProtKB:O75469)

GNAT1(UniProtKB:P11488)

PLEKHH3(UniProtKB:Q7Z736)

SIPA1(UniProtKB:Q96FS4)

IL18R1(UniProtKB:Q13478)

STMN1(UniProtKB:P16949)

SIRPB1(UniProtKB:O00241)

AIMP1(UniProtKB:Q12904)

RASL10B(UniProtKB:Q96S79)

CMTM2(UniProtKB:Q8TAZ6)

ARHGAP11B(UniProtKB:Q3KRB8)

ASIC3(UniProtKB:Q9UHC3)

PYY2(UniProtKB:Q9NRI6)

INS-IGF2(UniProtKB:F8WCM5)

PAG1(UniProtKB:Q9NWQ8)

PLAUR(UniProtKB:Q03405)

HUNK(UniProtKB:P57058)

HIF1A(UniProtKB:Q16665)

ARHGAP44(UniProtKB:Q17R89)

PDE11A(UniProtKB:Q9HCR9)

RGMB(UniProtKB:Q6NW40)

IL7R(UniProtKB:P16871)

EDN3(UniProtKB:P14138)

RASGRP2(UniProtKB:Q7LDG7)

RARA(UniProtKB:P10276)

PYCARD(UniProtKB:Q9ULZ3)

ERFE(UniProtKB:Q4G0M1)

CASP1(UniProtKB:P29466)

IL2RB(UniProtKB:P14784)

CD74(UniProtKB:P04233)

PI4KB(UniProtKB:Q9UBF8)

GABRD(UniProtKB:O14764)

GNA14(UniProtKB:O95837)

GABRR1(UniProtKB:P24046)

SMPD1(UniProtKB:P17405)

SYDE1(UniProtKB:Q6ZW31)

CHRNA9(UniProtKB:Q9UGM1)

PILRA(UniProtKB:Q9UKJ1)

NCR1(UniProtKB:O76036)

PLXNB1(UniProtKB:O43157)

VIPR2(UniProtKB:P41587)

IL10RB(UniProtKB:Q08334)

OPTN(UniProtKB:Q96CV9)

OGT(UniProtKB:O15294)

ITK(UniProtKB:Q08881)

KIR2DL4(UniProtKB:Q99706)

P2RX6(UniProtKB:O15547)

GNRH1(UniProtKB:P01148)

TNFRSF10A(UniProtKB:O00220)

CSNK2A1(UniProtKB:P68400)

IGFBP1(UniProtKB:P08833)

SMAD5-AS1(UniProtKB:Q9Y6J3)

EPGN(UniProtKB:Q6UW88)

SH3GL2(UniProtKB:Q99962)

EDNRA(UniProtKB:P25101)

ZACN(UniProtKB:Q401N2)

ESR2(UniProtKB:Q92731)

ARHGAP17(UniProtKB:Q68EM7)

TNFRSF17(UniProtKB:Q02223)

NPHP4(UniProtKB:O75161)

PKP1(UniProtKB:Q13835)

ADGRA1(UniProtKB:Q86SQ6)

LILRB1(UniProtKB:Q8NHL6)

CD86(UniProtKB:P42081)

HSH2D(UniProtKB:Q96JZ2)

NRP1(UniProtKB:O14786)

NPR1(UniProtKB:P16066)

RHEB(UniProtKB:Q15382)

TOM1L1(UniProtKB:O75674)

TNFRSF18(UniProtKB:Q9Y5U5)

LRP12(UniProtKB:Q9Y561)

C1QTNF12(UniProtKB:Q5T7M4)

RASD2(UniProtKB:Q96D21)

RAP1GAP(UniProtKB:P47736)

PDE8B(UniProtKB:A0A2R8Y4E6)

DLG5(UniProtKB:Q8TDM6)

NBL1(UniProtKB:P41271)

ACVR2B(UniProtKB:Q13705)

IGFBP6(UniProtKB:P24592)

ADORA1(UniProtKB:P30542)

ARHGAP10(UniProtKB:A1A4S6)

NTS(UniProtKB:P30990)

GABRR2(UniProtKB:P28476)

DAPP1(UniProtKB:Q9UN19)

TFF1(UniProtKB:P04155)

SFRP5(UniProtKB:Q5T4F7)

CNTF(UniProtKB:P26441)

TENM4(UniProtKB:Q6N022)

CAMK4(UniProtKB:Q16566)

PTGES(UniProtKB:O14684)

COPA(UniProtKB:P53621)

ARL2BP(UniProtKB:Q9Y2Y0)

IL17D(UniProtKB:Q8TAD2)

CCL7(UniProtKB:P80098)

OSTF1(UniProtKB:Q92882)

OXT(UniProtKB:P01178)

CGB3(UniProtKB:P0DN86)

HNRNPK(UniProtKB:P61978)

RIPK3(UniProtKB:Q9Y572)

CHRNA10(UniProtKB:Q9GZZ6)

CGB7(UniProtKB:P0DN87)

BARGIN(UniProtKB:Q6ZT62)

NSMAF(UniProtKB:Q92636)

EREG(UniProtKB:O14944)

GRN(UniProtKB:P28799)

STOML3(UniProtKB:Q8TAV4)

EGFR(UniProtKB:P00533)

CXCL12(UniProtKB:P48061)

ITPR1(UniProtKB:Q14643)

TANK(UniProtKB:Q92844)

ADRA1A(UniProtKB:P35348)

RIN3(UniProtKB:Q8TB24)

CD4(UniProtKB:P01730)

HPCAL4(UniProtKB:Q9UM19)

YWHAZ(UniProtKB:P63104)

IRS4(UniProtKB:O14654)

CD83(UniProtKB:Q01151)

LGALS3BP(UniProtKB:Q08380)

GABRP(UniProtKB:O00591)

CD80(UniProtKB:P33681)

IQGAP2(UniProtKB:Q13576)

SAV1(UniProtKB:Q9H4B6)

IL17B(UniProtKB:Q9UHF5)

CSNK1E(UniProtKB:P49674)

TNFRSF10D(UniProtKB:Q9UBN6)

CHRNA5(UniProtKB:P30532)

TRADD(UniProtKB:Q15628)

CAP2(UniProtKB:P40123)

CLOCK(UniProtKB:O15516)

TNFSF13B(UniProtKB:Q9Y275)

RALBP1(UniProtKB:Q15311)

IGF1R(UniProtKB:P08069)

PRKCB(UniProtKB:P05771)

IAPP(UniProtKB:P10997)

RASGRP1(UniProtKB:O95267)

GIP(UniProtKB:P09681)

FAS(UniProtKB:P25445)

PDGFRB(UniProtKB:P09619)

HDGF(UniProtKB:P51858)

REM1(UniProtKB:O75628)

CXCL8(UniProtKB:P10145)

APBB1(UniProtKB:O00213)

AKT2(UniProtKB:P31751)

OPN1SW(UniProtKB:P03999)

HTR3B(UniProtKB:O95264)

RLN1(UniProtKB:P04808)

PRR5-ARHGAP8(UniProtKB:B1AHC4)

CARTPT(UniProtKB:Q16568)

RIN1(UniProtKB:Q13671)

RALA(UniProtKB:P11233)

FGF20(UniProtKB:Q9NP95)

CCL4(UniProtKB:P13236)

ROR2(UniProtKB:Q01974)

GPR173(UniProtKB:Q9NS66)

CCND3(UniProtKB:P30281)

CSPG5(UniProtKB:O95196)

CNTFR(UniProtKB:P26992)

CSNK1G2(UniProtKB:P78368)

SMAD1(UniProtKB:Q15797)

CLEC5A(UniProtKB:Q9NY25)

LOC102723996(UniProtKB:A0A087X1L8)

TAFA5(UniProtKB:Q7Z5A7)

TNFSF10(UniProtKB:P50591)

TLE1(UniProtKB:Q04724)

CSNK2B(UniProtKB:P67870)

PPP1R1B(UniProtKB:Q9UD71)

PKIG(UniProtKB:Q9Y2B9)

RAC2(UniProtKB:P15153)

GRB14(UniProtKB:Q14449)

TNFSF12-TNFSF13(UniProtKB:A0A0A6YY99)

HSP90AA1(UniProtKB:P07900)

TNFRSF11B(UniProtKB:O00300)

TAAR5(UniProtKB:O14804)

CAMK2B(UniProtKB:Q13554)

PITPNC1(UniProtKB:Q9UKF7)

STK3(UniProtKB:Q13188)

CHRNA4(UniProtKB:P43681)

BTRC(UniProtKB:Q9Y297)

STARD13(UniProtKB:Q9Y3M8)

IGBP1(UniProtKB:P78318)

DLC1(UniProtKB:Q96QB1)

TEK(UniProtKB:Q02763)

IL4R(UniProtKB:P24394)

ZPR1(UniProtKB:O75312)

STAT3(UniProtKB:P40763)

CMTM5(UniProtKB:Q96DZ9)

TLE2(UniProtKB:Q04725)

ZYX(UniProtKB:Q15942)

MAP2K7(UniProtKB:O14733)

HGS(UniProtKB:O14964)

CHRM1(UniProtKB:P11229)

MAPK10(UniProtKB:P53779)

CDC42SE1(UniProtKB:Q9NRR8)

FAM3C(UniProtKB:Q92520)

FRS3(UniProtKB:O43559)

IQGAP1(UniProtKB:P46940)

TAFA4(UniProtKB:Q96LR4)

ARHGAP25(UniProtKB:P42331)

OR52A1(UniProtKB:Q9UKL2)

RARB(UniProtKB:P10826)

IGFALS(UniProtKB:P35858)

TEX2(UniProtKB:Q8IWB9)

PRKAA2(UniProtKB:P54646)

GNA13(UniProtKB:Q14344)

TOLLIP(UniProtKB:Q9H0E2)

ENHO(UniProtKB:Q6UWT2)

FEZ2(UniProtKB:Q9UHY8)

PDE7B(UniProtKB:Q9NP56)

M0QZQ0(UniProtKB:M0QZQ0)

STARD8(UniProtKB:Q92502)

CCL26(UniProtKB:Q9Y258)

FAM3D(UniProtKB:Q96BQ1)

GABRB1(UniProtKB:P18505)

ASIP(UniProtKB:P42127)

JAK2(UniProtKB:O60674)

TNFRSF25(UniProtKB:Q93038)

ADCY9(UniProtKB:O60503)

NDRG1(UniProtKB:Q92597)

TMEM102(UniProtKB:Q8N9M5)

CKLF(UniProtKB:Q9UBR5)

ECM1(UniProtKB:Q16610)

CAPN5(UniProtKB:O15484)

PPFIA1(UniProtKB:Q13136)

STK25(UniProtKB:O00506)

BCAR3(UniProtKB:O75815)

GKAP1(UniProtKB:Q5VSY0)

OR2F1(UniProtKB:Q13607)

GFRA3(UniProtKB:O60609)

CXCL11(UniProtKB:O14625)

PPP2R5D(UniProtKB:Q14738)

CSF1R(UniProtKB:P07333)

CHRNA7(UniProtKB:P36544)

CRHBP(UniProtKB:P24387)

GFER(UniProtKB:P55789)

GABRB2(UniProtKB:P47870)

NRG2(UniProtKB:O14511)

SOX8(UniProtKB:P57073)

RABEP2(UniProtKB:Q9H5N1)

NCR2(UniProtKB:O95944)

WISP1(UniProtKB:O95388)

IL1RL2(UniProtKB:Q9HB29)

KCNIP3(UniProtKB:Q9Y2W7)

CHRNB2(UniProtKB:P17787)

RADIL(UniProtKB:Q96JH8)

NR2F2(UniProtKB:P24468)

SPP1(UniProtKB:P10451)

TRIM54(UniProtKB:Q9BYV2)

ANGPT2(UniProtKB:O15123)

NCK2(UniProtKB:O43639)

PRKG2(UniProtKB:Q13237)

CALCOCO1(UniProtKB:Q9P1Z2)

IGF2R(UniProtKB:P11717)

ADA2(UniProtKB:Q9NZK5)

DOCK1(UniProtKB:Q14185)

CCR6(UniProtKB:P51684)

CD164(UniProtKB:Q04900)

NPM1(UniProtKB:P06748)

SH3BP5(UniProtKB:O60239)

GNG11(UniProtKB:P61952)

MACC1(UniProtKB:Q6ZN28)

ERBB3(UniProtKB:P21860)

PKN1(UniProtKB:Q16512)

ATF6(UniProtKB:P18850)

CHL1(UniProtKB:O00533)

OR3A1(UniProtKB:P47881)

PRMT2(UniProtKB:P55345)

RASAL2(UniProtKB:Q9UJF2)

EXT2(UniProtKB:Q93063)

FASLG(UniProtKB:P48023)

PLAU(UniProtKB:P00749)

RASIP1(UniProtKB:Q5U651)

PRKG1(UniProtKB:Q13976)

ESR1(UniProtKB:P03372)

SH3BP2(UniProtKB:P78314)

NPHP1(UniProtKB:O15259)

TTR(UniProtKB:P02766)

RASSF4(UniProtKB:Q9H2L5)

SPX(UniProtKB:Q9BT56)

DPYSL2(UniProtKB:Q16555)

PDE1C(UniProtKB:Q14123)

VLDLR(UniProtKB:P98155)

INPP1(UniProtKB:P49441)

PPP1R12C(UniProtKB:Q9BZL4)

PI4KA(UniProtKB:P42356)

DLG4(UniProtKB:P78352)

COL4A3BP(UniProtKB:Q9Y5P4)

IGFBP5(UniProtKB:P24593)

PCNT(UniProtKB:O95613)

CCL22(UniProtKB:O00626)

PECAM1(UniProtKB:P16284)

LILRB4(UniProtKB:Q8NHJ6)

GRASP(UniProtKB:Q7Z6J2)

NEDD9(UniProtKB:Q14511)

IL21(UniProtKB:Q9HBE4)

SNX17(UniProtKB:Q15036)

OR6A2(UniProtKB:O95222)

RASSF9(UniProtKB:O75901)

P2RX1(UniProtKB:P51575)

CHRNE(UniProtKB:Q04844)

RANGAP1(UniProtKB:P46060)

DOK1(UniProtKB:Q99704)

NLRP3(UniProtKB:Q96P20)

CSF2RB(UniProtKB:P32927)

TYRO3(UniProtKB:Q06418)

FGF1(UniProtKB:P05230)

CCL23(UniProtKB:P55773)

RASL11B(UniProtKB:Q9BPW5)

ITGB3BP(UniProtKB:Q13352)

ARHGAP12(UniProtKB:Q8IWW6)

TP53BP2(UniProtKB:Q13625)

VAV2(UniProtKB:P52735)

SPN(UniProtKB:P16150)

SH3GL3(UniProtKB:Q99963)

DNM2(UniProtKB:P50570)

RPS6KA3(UniProtKB:P51812)

RASSF3(UniProtKB:Q86WH2)

AMELX(UniProtKB:Q99217)

MAPKAPK5(UniProtKB:Q8IW41)

PENK(UniProtKB:P01210)

CRABP2(UniProtKB:P29373)

NR2F1(UniProtKB:P10589)

ARHGAP36(UniProtKB:Q6ZRI8)

CMTM3(UniProtKB:Q96MX0)

CCL15(UniProtKB:Q16663)

PPP2R5C(UniProtKB:Q13362)

TRAF5(UniProtKB:O00463)

ARHGAP9(UniProtKB:Q9BRR9)

ARAP1(UniProtKB:Q96P48)

PDE5A(UniProtKB:O76074)

STAM(UniProtKB:Q92783)

GRIA2(UniProtKB:P42262)

AKAP10(UniProtKB:O43572)

BABAM2(UniProtKB:Q9NXR7)

PPP1R12B(UniProtKB:O60237)

MAPK12(UniProtKB:P53778)

WNT8B(UniProtKB:Q93098)

GDI2(UniProtKB:P50395)

RALB(UniProtKB:P11234)

ERBB4(UniProtKB:Q15303)

MET(UniProtKB:P08581)

TAGAP(UniProtKB:Q8N103)

NOD1(UniProtKB:Q9Y239)

RIT1(UniProtKB:Q92963)

CREM(UniProtKB:Q03060)

IL12RB1(UniProtKB:P42701)

OR3A3(UniProtKB:P47888)

IMPA2(UniProtKB:O14732)

THBS4(UniProtKB:P35443)

PRKAA1(UniProtKB:Q13131)

CLCN6(UniProtKB:P51797)

TIE1(UniProtKB:P35590)

SRGAP1(UniProtKB:Q7Z6B7)

CMTM8(UniProtKB:Q8IZV2)

BTC(UniProtKB:P35070)

RTKN2(UniProtKB:Q8IZC4)

HHIP(UniProtKB:Q96QV1)

HTR3D(UniProtKB:Q70Z44)

NRGN(UniProtKB:Q92686)

MDK(UniProtKB:P21741)

OGN(UniProtKB:P20774)

ATF6B(UniProtKB:Q99941)

STAC(UniProtKB:Q99469)

OR5I1(UniProtKB:Q13606)

RASL12(UniProtKB:Q9NYN1)

GDI1(UniProtKB:P31150)

ITPK1(UniProtKB:Q13572)

ARHGAP21(UniProtKB:Q5T5U3)

CASKIN1(UniProtKB:Q8WXD9)

FLNB(UniProtKB:O75369)

SCGB1A1(UniProtKB:P11684)

PAK5(UniProtKB:Q9P286)

GNA11(UniProtKB:P29992)

TAFA1(UniProtKB:Q7Z5A9)

GUCA2A(UniProtKB:Q02747)

INPP4B(UniProtKB:O15327)

GABRB3(UniProtKB:P28472)

CCL13(UniProtKB:Q99616)

RASA3(UniProtKB:Q14644)

LILRA2(UniProtKB:Q8N149)

NDRG2(UniProtKB:Q9UN36)

RABEP1(UniProtKB:Q15276)

KLRC2(UniProtKB:P26717)

TOM1L2(UniProtKB:Q6ZVM7)

PDCL(UniProtKB:Q13371)

FLT3LG(UniProtKB:P49771)

MAP2K3(UniProtKB:P46734)

CXCL5(UniProtKB:P42830)

PLA2G1B(UniProtKB:P04054)

IPO8(UniProtKB:O15397)

TYMP(UniProtKB:P19971)

PTGES3(UniProtKB:Q15185)

GPR85(UniProtKB:P60893)

GREM1(UniProtKB:O60565)

CDKL2(UniProtKB:Q92772)

TIPRL(UniProtKB:O75663)

PTPRT(UniProtKB:O14522)

CACNA1I(UniProtKB:Q9P0X4)

AR(UniProtKB:P10275)

CCL8(UniProtKB:P80075)

CHRNB4(UniProtKB:P30926)

PRKCE(UniProtKB:Q02156)

GAST(UniProtKB:P01350)

LTA(UniProtKB:P01374)

BCAM(UniProtKB:P50895)

STC1(UniProtKB:P52823)

CSF3R(UniProtKB:Q99062)

GUCY1A2(UniProtKB:P33402)

DIRAS1(UniProtKB:O95057)

AMFR(UniProtKB:Q9UKV5)

FCGR2B(UniProtKB:P31994)

ACVR1B(UniProtKB:P36896)

GRK7(UniProtKB:Q8WTQ7)

ARHGAP24(UniProtKB:Q8N264)

LTK(UniProtKB:P29376)

SH2D2A(UniProtKB:Q9NP31)

DDR2(UniProtKB:Q16832)

GNRH2(UniProtKB:O43555)

TNFAIP6(UniProtKB:P98066)

CHRNA6(UniProtKB:Q15825)

COL15A1(UniProtKB:P39059)

ANKDD1A(UniProtKB:Q495B1)

ARHGAP35(UniProtKB:Q9NRY4)

FGF2(UniProtKB:P09038)

CD70(UniProtKB:P32970)

BMX(UniProtKB:P51813)

CD320(UniProtKB:Q9NPF0)

RNF14(UniProtKB:Q9UBS8)

SOX9(UniProtKB:P48436)

FGFBP1(UniProtKB:Q14512)

RYK(UniProtKB:P34925)

CCL2(UniProtKB:P13500)

CLIC1(UniProtKB:O00299)

GABRA3(UniProtKB:P34903)

CD200R1(UniProtKB:Q8TD46)

IL1B(UniProtKB:P01584)

ARHGAP27(UniProtKB:Q6ZUM4)

ADORA3(UniProtKB:P0DMS8)

LTB(UniProtKB:Q06643)

GLRB(UniProtKB:P48167)

MICAL1(UniProtKB:Q8TDZ2)

HBS1L(UniProtKB:Q9Y450)

CHRNA3(UniProtKB:P32297)

SRGAP2(UniProtKB:O75044)

PEX11A(UniProtKB:O75192)

CBLC(UniProtKB:Q9ULV8)

CXCL10(UniProtKB:P02778)

CNTNAP1(UniProtKB:P78357)

PTK7(UniProtKB:Q13308)

PIK3CD(UniProtKB:O00329)

MPP1(UniProtKB:Q00013)

ITPKB(UniProtKB:P27987)

SFN(UniProtKB:P31947)

GLRA4(UniProtKB:Q5JXX5)

PXN(UniProtKB:P49023)

SRGAP3(UniProtKB:O43295)

MADCAM1(UniProtKB:Q13477)

RASL11A(UniProtKB:Q6T310)

CCN3(UniProtKB:P48745)

MYD88(UniProtKB:Q99836)

STX2(UniProtKB:P32856)

CD79B(UniProtKB:P40259)

GMFG(UniProtKB:O60234)

ANGPTL3(UniProtKB:Q9Y5C1)

APLN(UniProtKB:Q9ULZ1)

RTKN(UniProtKB:Q9BST9)

GAPVD1(UniProtKB:Q14C86)

FCGR1A(UniProtKB:P12314)

CORO1C(UniProtKB:Q9ULV4)

APPL2(UniProtKB:Q8NEU8)

NET1(UniProtKB:Q7Z628)

FGF18(UniProtKB:O76093)

FGD1(UniProtKB:P98174)

GNL1(UniProtKB:P36915)

PDE4A(UniProtKB:P27815)

IL5RA(UniProtKB:Q01344)

C5AR1(UniProtKB:P21730)

WWP1(UniProtKB:Q9H0M0)

GLRA3(UniProtKB:O75311)

ANKDD1B(UniProtKB:A6NHY2)

ICOSLG(UniProtKB:O75144)

PEX11B(UniProtKB:O96011)

PMCHL2(UniProtKB:Q9BQD1)

GPR27(UniProtKB:Q9NS67)

PPP1R12A(UniProtKB:O14974)

TGFBRAP1(UniProtKB:Q8WUH2)

WISP2(UniProtKB:O76076)

ARAP3(UniProtKB:Q8WWN8)

IL1RAPL1(UniProtKB:Q9NZN1)

RASA1(UniProtKB:P20936)

CXCL14(UniProtKB:O95715)

CDC42BPB(UniProtKB:Q9Y5S2)

PSTPIP1(UniProtKB:O43586)

CAMK1(UniProtKB:Q14012)

RBPJL(UniProtKB:Q9UBG7)

GABRG3(UniProtKB:Q99928)

PRKCH(UniProtKB:P24723)

P2RX5(UniProtKB:Q93086)

MIA(UniProtKB:Q16674)

NMB(UniProtKB:P08949)

GLRA2(UniProtKB:P23416)

CABP5(UniProtKB:Q9NP86)

CCL20(UniProtKB:P78556)

ADCY8(UniProtKB:P40145)

GDNF(UniProtKB:P39905)

CASP8AP2(UniProtKB:Q9UKL3)

LIMD1(UniProtKB:Q9UGP4)

HTR3A(UniProtKB:P46098)

AKAP4(UniProtKB:Q5JQC9)

GNGT1(UniProtKB:P63211)

PRKCD(UniProtKB:Q05655)

TRAT1(UniProtKB:Q6PIZ9)

GNB5(UniProtKB:O14775)

GMFB(UniProtKB:P60983)

PRKD1(UniProtKB:Q15139)

ACTL6A(UniProtKB:O96019)

RETNLB(UniProtKB:Q9BQ08)

GABRR3(UniProtKB:A8MPY1)

C3(UniProtKB:P01024)

INPP5D(UniProtKB:Q92835)

NRXN2(UniProtKB:Q9P2S2)

LSP1(UniProtKB:P33241)

AXL(UniProtKB:P30530)

SMAD5(UniProtKB:Q99717)

GUCA1C(UniProtKB:O95843)

APPL1(UniProtKB:Q9UKG1)

FGF7(UniProtKB:P21781)

MAP3K10(UniProtKB:Q02779)

AKT3(UniProtKB:Q9Y243)

MX1(UniProtKB:P20591)

NPR2(UniProtKB:P20594)

PDAP1(UniProtKB:Q13442)

VGF(UniProtKB:O15240)

FAM3B(UniProtKB:P58499)

RPS6KA2(UniProtKB:Q15349)

CHGB(UniProtKB:P05060)

SNX27(UniProtKB:Q96L92)

RHPN1(UniProtKB:Q8TCX5)

RASSF8(UniProtKB:Q8NHQ8)

PIP5K1A(UniProtKB:Q99755)

GUCY2D(UniProtKB:Q02846)

LALBA(UniProtKB:P00709)

NR2E3(UniProtKB:Q9Y5X4)

TGFBR1(UniProtKB:P36897)

DOK2(UniProtKB:O60496)

THNSL2(UniProtKB:Q86YJ6)

MANF(UniProtKB:P55145)

RAPH1(UniProtKB:Q70E73)

VAC14(UniProtKB:Q08AM6)

ADCY3(UniProtKB:O60266)

CCL24(UniProtKB:O00175)

TRAF4(UniProtKB:Q9BUZ4)

ERBIN(UniProtKB:Q96RT1)

CALML5(UniProtKB:Q9NZT1)

CLIC2(UniProtKB:O15247)

STK24(UniProtKB:Q9Y6E0)

AKAP9(UniProtKB:Q99996)

HLA-DRB3(UniProtKB:P79483)

ANXA4(UniProtKB:P09525)

CABP2(UniProtKB:Q9NPB3)

TLR2(UniProtKB:O60603)

FGF16(UniProtKB:O43320)

P2RX3(UniProtKB:P56373)

RPS6KB1(UniProtKB:P23443)

RAF1(UniProtKB:P04049)

TYROBP(UniProtKB:O43914)

TDGF1P3(UniProtKB:P51864)

IRS2(UniProtKB:Q9Y4H2)

EXT1(UniProtKB:Q16394)

C1QTNF9(UniProtKB:P0C862)

FGF4(UniProtKB:P08620)

MRGPRX1(UniProtKB:Q96LB2)

GJA1(UniProtKB:P17302)

SHB(UniProtKB:Q15464)

CHRNA1(UniProtKB:P02708)

NR3C2(UniProtKB:P08235)

CREBL2(UniProtKB:O60519)

IL1RL1(UniProtKB:Q01638)

NDRG3(UniProtKB:Q9UGV2)

PDCD1LG2(UniProtKB:Q9BQ51)

NR3C1(UniProtKB:P04150)

PGR(UniProtKB:P06401)

IL19(UniProtKB:Q9UHD0)

INPP4A(UniProtKB:Q96PE3)

PRKAB2(UniProtKB:O43741)

IPO7(UniProtKB:O95373)

CHRNG(UniProtKB:P07510)

GPNMB(UniProtKB:Q14956)

ALCAM(UniProtKB:Q13740)

TNFSF18(UniProtKB:Q9UNG2)

BRD8(UniProtKB:Q9H0E9)

GUCY2F(UniProtKB:P51841)

ARHGAP20(UniProtKB:Q9P2F6)

ARHGAP15(UniProtKB:Q53QZ3)

EGF(UniProtKB:P01133)

S100A11(UniProtKB:P31949)

ARFRP1(UniProtKB:Q13795)

PTK2B(UniProtKB:Q14289)

MST1R(UniProtKB:Q04912)

ARHGEF7(UniProtKB:Q14155)

PPP4R1(UniProtKB:Q8TF05)

THOC1(UniProtKB:Q96FV9)

INSL4(UniProtKB:Q14641)

GNAI2(UniProtKB:P04899)

TNFSF15(UniProtKB:O95150)

FAM13A(UniProtKB:O94988)

ELK3(UniProtKB:P41970)

GNB4(UniProtKB:Q9HAV0)

DGKG(UniProtKB:P49619)

PKN2(UniProtKB:Q16513)

GABRA5(UniProtKB:P31644)

GABRA4(UniProtKB:P48169)

IRAK1(UniProtKB:P51617)

CSNK1A1(UniProtKB:P48729)

OR1E2(UniProtKB:P47887)

GABRQ(UniProtKB:Q9UN88)

INSL6(UniProtKB:Q9Y581)

PLAA(UniProtKB:Q9Y263)

TLR1(UniProtKB:Q15399)

TNFSF12(UniProtKB:O43508)

HTR3C(UniProtKB:Q8WXA8)

TNFSF13(UniProtKB:O75888)

TNFSF4(UniProtKB:P23510)

PRKAG1(UniProtKB:P54619)

STAT6(UniProtKB:P42226)

HAMP(UniProtKB:P81172)

ARAP2(UniProtKB:Q8WZ64)

ITGAL(UniProtKB:P20701)

DPYSL5(UniProtKB:Q9BPU6)

ASIC1(UniProtKB:P78348)

KALRN(UniProtKB:O60229)

DGKD(UniProtKB:Q16760)

MAP2K5(UniProtKB:Q13163)

PAK2(UniProtKB:Q13177)

FGF13(UniProtKB:Q92913)

ARHGAP28(UniProtKB:Q9P2N2)

AKT1(UniProtKB:P31749)

GABRG1(UniProtKB:Q8N1C3)

MAGI1(UniProtKB:Q96QZ7)

TLE3(UniProtKB:Q04726)

PMCHL1(UniProtKB:Q16048)

NR1I3(UniProtKB:Q14994)

SIGIRR(UniProtKB:Q6IA17)

SIT1(UniProtKB:Q9Y3P8)

CD34(UniProtKB:P28906)

FGF3(UniProtKB:P11487)

TRAF1(UniProtKB:Q13077)

AFDN(UniProtKB:P55196)

GABRA6(UniProtKB:Q16445)

NAE1(UniProtKB:Q13564)

FGF21(UniProtKB:Q9NSA1)

OR1G1(UniProtKB:P47890)

OPHN1(UniProtKB:O60890)

CSNK1G3(UniProtKB:Q9Y6M4)

ING2(UniProtKB:Q9H160)

TRIM55(UniProtKB:Q9BYV6)

PIK3CB(UniProtKB:P42338)

DIAPH2-AS1(UniProtKB:Q14236)

TRIP10(UniProtKB:Q15642)

GNB1(UniProtKB:P62873)

PRKCZ(UniProtKB:Q05513)

LILRA3(UniProtKB:Q8N6C8)

C1QTNF4(UniProtKB:Q9BXJ3)

GAS6(UniProtKB:Q14393)

MAPK14(UniProtKB:Q16539)

DLL4(UniProtKB:Q9NR61)

CD2AP(UniProtKB:Q9Y5K6)

ARHGAP19(UniProtKB:Q14CB8)

CHRM4(UniProtKB:P08173)

PAK4(UniProtKB:O96013)

GTF2I(UniProtKB:P78347)

ITGB1BP2(UniProtKB:Q9UKP3)

GNG12(UniProtKB:Q9UBI6)

CXCL9(UniProtKB:Q07325)

RGS1(UniProtKB:Q08116)

OCRL(UniProtKB:Q01968)

ITPKA(UniProtKB:P23677)

NR4A2(UniProtKB:P43354)

RND2(UniProtKB:P52198)

TPTE(UniProtKB:P56180)

GNG10(UniProtKB:P50151)

FAM13B(UniProtKB:Q9NYF5)

TRIM63(UniProtKB:Q969Q1)

ATM(UniProtKB:Q13315)

RASAL1(UniProtKB:O95294)

ARHGAP40(UniProtKB:Q5TG30)

PLCB1(UniProtKB:Q9NQ66)

NFKBIB(UniProtKB:Q15653)

MCC(UniProtKB:P23508)

PRKAB1(UniProtKB:Q9Y478)

GTPBP1(UniProtKB:O00178)

CYTL1(UniProtKB:Q9NRR1)

IMPA1(UniProtKB:P29218)

NDRG4(UniProtKB:Q9ULP0)

NOX1(UniProtKB:Q9Y5S8)

CD244(UniProtKB:Q9BZW8)

LRRN2(UniProtKB:O75325)

SIGLEC8(UniProtKB:Q9NYZ4)

RCAN1(UniProtKB:P53805)

HRAS(UniProtKB:P01112)

ITPR2(UniProtKB:Q14571)

RAPGEF1(UniProtKB:Q13905)

NFAM1(UniProtKB:Q8NET5)

IGFBP2(UniProtKB:P18065)

DTNA(UniProtKB:Q9Y4J8)

CNGA3(UniProtKB:Q16281)

DIRAS2(UniProtKB:Q96HU8)

CCK(UniProtKB:P06307)

CDNF(UniProtKB:Q49AH0)

ARHGAP26(UniProtKB:Q9UNA1)

AGRN(UniProtKB:O00468)

CHRM3(UniProtKB:P20309)

UTS2R(UniProtKB:Q9UKP6)

SLC39A4(UniProtKB:Q6P5W5)

IL2RG(UniProtKB:P31785)

FGF11(UniProtKB:Q92914)

GNG5(UniProtKB:P63218)

RASD1(UniProtKB:Q9Y272)

POMC(UniProtKB:P01189)

CDC42EP3(UniProtKB:Q9UKI2)

NAMPT(UniProtKB:P43490)

TNFRSF11A(UniProtKB:Q9Y6Q6)

TRAIP(UniProtKB:Q9BWF2)

VSTM1(UniProtKB:Q6UX27)

GUCA1A(UniProtKB:P43080)

FPR3(UniProtKB:P25089)

LRP8(UniProtKB:Q14114)

NTF3(UniProtKB:P20783)

TG(UniProtKB:P01266)

RASSF7(UniProtKB:Q02833)

ANGPTL8(UniProtKB:Q6UXH0)

ADIPOQ(UniProtKB:Q15848)

ANK1(UniProtKB:P16157)

SYDE2(UniProtKB:Q5VT97)

XCL1(UniProtKB:P47992)

RASGRF1(UniProtKB:Q13972)

RIPK2(UniProtKB:O43353)

PTPRK(UniProtKB:Q15262)

LIMK1(UniProtKB:P53667)

APBB1IP(UniProtKB:Q7Z5R6)

KIF13B(UniProtKB:Q9NQT8)

CMTM1(UniProtKB:Q8IZ96)

GABRA1(UniProtKB:P14867)

DEK(UniProtKB:P35659)

PPP2R5E(UniProtKB:Q16537)

BST1(UniProtKB:Q10588)

CD226(UniProtKB:Q15762)

LMBR1L(UniProtKB:Q6UX01)

GABRA2(UniProtKB:P47869)

RHPN2(UniProtKB:Q8IUC4)

REM2(UniProtKB:Q8IYK8)

CRH(UniProtKB:P06850)

HPGDS(UniProtKB:O60760)

KIFAP3(UniProtKB:Q92845)

GRK3(UniProtKB:P35626)

CDS1(UniProtKB:Q92903)

TENM3(UniProtKB:Q9P273)

CAP1(UniProtKB:Q01518)

TBXT(UniProtKB:O15178)

GRK4(UniProtKB:P32298)

ADM(UniProtKB:P35318)

PTPRM(UniProtKB:P28827)

TENM2(UniProtKB:Q9NT68)

MAVS(UniProtKB:Q7Z434)

PPP2R5A(UniProtKB:Q15172)

GDF15(UniProtKB:Q99988)

KCNIP2(UniProtKB:Q9NS61)

CCL1(UniProtKB:P22362)

LILRB2(UniProtKB:Q8N423)

OSGIN2(UniProtKB:Q9Y236)

RETN(UniProtKB:Q9HD89)

CCL18(UniProtKB:P55774)

GPR143(UniProtKB:P51810)

DTHD1(UniProtKB:Q6ZMT9)

CNGB3(UniProtKB:Q9NQW8)

ASB2(UniProtKB:Q96Q27)

PHB(UniProtKB:P35232)

ZFYVE16(UniProtKB:Q7Z3T8)

RPS6KA1(UniProtKB:Q15418)

CLIC3(UniProtKB:O95833)

BMP1(UniProtKB:P13497)

EPAS1(UniProtKB:Q99814)

LYN(UniProtKB:P07948)

TRHDE(UniProtKB:Q9UKU6)

CCN6(UniProtKB:O95389)

AVP(UniProtKB:P01185)

TRAF2(UniProtKB:Q12933)

C17orf99(UniProtKB:Q6UX52)

PGF(UniProtKB:P49763)

VEGFC(UniProtKB:P49767)

PLCG1(UniProtKB:P19174)

RPS6KB2(UniProtKB:Q9UBS0)

RPS6KC1(UniProtKB:Q96S38)

TLR6(UniProtKB:Q9Y2C9)

RASA2(UniProtKB:Q15283)

IL9R(UniProtKB:Q01113)

SH2B2(UniProtKB:O14492)

KRT17(UniProtKB:Q04695)

S100A6(UniProtKB:P06703)

FGF12(UniProtKB:P61328)

PNOC(UniProtKB:Q13519)

ARHGAP11A(UniProtKB:Q6P4F7)

RET(UniProtKB:P07949)

ADGRB1(UniProtKB:O14514)

CHRND(UniProtKB:Q07001)

ALK(UniProtKB:Q9UM73)

MAGI2(UniProtKB:Q86UL8)

CMTM7(UniProtKB:Q96FZ5)

MAPT(UniProtKB:P10636)

ANXA5(UniProtKB:P08758)

WIF1(UniProtKB:Q9Y5W5)

PLCXD3(UniProtKB:Q63HM9)

ULK1(UniProtKB:O75385)

CREBBP(UniProtKB:Q92793)

ARHGAP23(UniProtKB:Q9P227)

AKAP8(UniProtKB:O43823)

ERBB2(UniProtKB:P04626)

GEM(UniProtKB:P55040)

CABP4(UniProtKB:P57796)

ANXA1(UniProtKB:P04083)

ROCK1(UniProtKB:Q13464)

SLC39A12(UniProtKB:Q504Y0)

KCNK10(UniProtKB:P57789)

FBN1(UniProtKB:P35555)

GABRE(UniProtKB:P78334)

OSGIN1(UniProtKB:Q9UJX0)

GNAL(UniProtKB:P38405)

COPS3(UniProtKB:Q9UNS2)

CALCB(UniProtKB:P10092)

GPRC5A(UniProtKB:Q8NFJ5)

ARHGAP42(UniProtKB:A6NI28)

DRG2(UniProtKB:P55039)

MOK(UniProtKB:Q9UQ07)

SERGEF(UniProtKB:Q9UGK8)

IL15(UniProtKB:P40933)

ABL2(UniProtKB:P42684)

GRIA1(UniProtKB:P42261)

C12orf81(UniProtKB:P0DPE3)

EPO(UniProtKB:P01588)

THAP12(UniProtKB:O43422)

AKAP5(UniProtKB:P24588)

CTNND2(UniProtKB:Q9UQB3)

TNFSF14(UniProtKB:O43557)

FNDC5(UniProtKB:Q8NAU1)

MAP2K1(UniProtKB:Q02750)

ARHGAP22(UniProtKB:Q7Z5H3)

AKAP17A(UniProtKB:Q02040)

ARR3(UniProtKB:P36575)

TGFA(UniProtKB:P01135)

MAGI3(UniProtKB:Q5TCQ9)

PRKACB(UniProtKB:P22694)

AREG(UniProtKB:P15514)

FPR1(UniProtKB:P21462)

GUCY2C(UniProtKB:P25092)

CHRNB3(UniProtKB:Q05901)

TRAF3(UniProtKB:Q13114)

CBLB(UniProtKB:Q13191)

CBL(UniProtKB:P22681)

CLEC11A(UniProtKB:Q9Y240)

CXCR2(UniProtKB:P25025)

PKN3(UniProtKB:Q6P5Z2)

NENF(UniProtKB:Q9UMX5)

CXCL1(UniProtKB:P09341)

CDK4(UniProtKB:P11802)

CHRNA2(UniProtKB:Q15822)

NFAT5(UniProtKB:O94916)

CD274(UniProtKB:Q9NZQ7)

ICK(UniProtKB:Q9UPZ9)

LTBR(UniProtKB:P36941)

IGFBP4(UniProtKB:P22692)

SPARCL1(UniProtKB:Q14515)

LPXN(UniProtKB:O60711)

PIDD1(UniProtKB:Q9HB75)

RAPGEF3(UniProtKB:O95398)

SPHK1(UniProtKB:Q9NYA1)

TMED1(UniProtKB:Q13445)

CREB1(UniProtKB:P16220)

AMBN(UniProtKB:Q9NP70)

METRNL(UniProtKB:Q641Q3)

GLRA1(UniProtKB:P23415)

LHB(UniProtKB:P01229)

AGAP3(UniProtKB:Q96P47)

SRI(UniProtKB:P30626)

PSD(UniProtKB:A5PKW4)

NR4A1(UniProtKB:P22736)

RAP2B(UniProtKB:P61225)

MTA1(UniProtKB:Q13330)

ACVRL1(UniProtKB:P37023)

XCL2(UniProtKB:Q9UBD3)

GATA3(UniProtKB:P23771)

NR2F6(UniProtKB:P10588)

CHRFAM7A(UniProtKB:Q494W8)

MAP3K6(UniProtKB:O95382)

ARHGAP8(UniProtKB:P85298)

PPP3CB(UniProtKB:P16298)

INPP5B(UniProtKB:P32019)

RHBDL1(UniProtKB:O75783)

GABRG2(UniProtKB:P18507)

MAPK1(UniProtKB:P28482)

GRP(UniProtKB:P07492)

INHA(UniProtKB:P05111)

TRIP6(UniProtKB:Q15654)

TLR3(UniProtKB:O15455)

HTR3E(UniProtKB:A5X5Y0)

TRH(UniProtKB:P20396)

CXCL6(UniProtKB:P80162)

SRC(UniProtKB:P12931)

ERG(UniProtKB:P11308)

CD38(UniProtKB:P28907)

FGF14(UniProtKB:Q92915)

SH3GL1(UniProtKB:Q99961)

BCR(UniProtKB:P11274)

OR1F1(UniProtKB:O43749)

IRS1(UniProtKB:P35568)

MKLN1(UniProtKB:Q9UL63)

label

Signal Transduction

MCID

MC04807838

PMOID

PMO:00063723

prefixIRI

pmo:PMO_00063723

prefLabel

Signal Transduction

Synonym

"signalling cascade" NARROW []

"signaling pathway" RELATED []

"signaling cascade" NARROW []

"signalling pathway" RELATED [GOC:mah]

Tree Number

T10.1.29.20

T10.1.26.1.33.23

subClassOf

http://www.phoc.org.cn/pmo/class/PMO_00062856

http://www.phoc.org.cn/pmo/class/PMO_00084188

Delete Subject Author Type Created
No notes to display
Create mapping

Mapping To Ontology Source
http://purl.obolibrary.org/obo/GO_0007165 UBERON LOOM
http://purl.obolibrary.org/obo/GO_0007165 CL LOOM
http://purl.obolibrary.org/obo/GO_0007165 OBA LOOM
http://purl.obolibrary.org/obo/GO_0007165 FYPO LOOM
http://purl.obolibrary.org/obo/WC_signalTransduction WC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0037083 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D015398 RH-MESH LOOM
http://purl.org/obo/owl/GO#GO_0007165 HUPSON LOOM
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