loading...| Preferred Name |
DNA Replication |
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| Synonyms |
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| Definitions |
A complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (DnaB or MCM complex) precedes the DNA synthetic machinery and unwinds the duplex parental DNA in cooperation with the SSB or RPA. On the leading strand, replication occurs continuously in a 5 to 3 direction, whereas on the lagging strand, DNA replication occurs discontinuously by synthesis and joining of short Okazaki fragments. In prokaryotes, the leading strand replication apparatus consists of a DNA polymerase (pol III core), a sliding clamp (beta), and a clamp loader (gamma delta complex). The DNA primase (DnaG) is needed to form RNA primers. Normally, during replication of the lagging-strand DNA template, an RNA primer is removed either by an RNase H or by the 5 to 3 exonuclease activity of DNA pol I, and the DNA ligase joins the Okazaki fragments. In eukaryotes, three DNA polymerases (alpha, delta, and epsilon) have been identified. DNA primase forms a permanent complex with DNA polymerase alpha. PCNA and RFC function as a clamp and a clamp loader. FEN 1 and RNase H1 remove the RNA from the Okazaki fragments and DNA ligase I joins the DNA. |
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| ID |
http://www.phoc.org.cn/pmo/class/PMO_00014497 |
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| Database_Cross_Reference |
MTH:NOCODE AOD:0000021658 AOD:0000001917 SNOMEDCT_US:74256009 SNMI:F-E2670 LCH_NW:sh90005926 CHV:0000041872 CSP:2102-4920 NCI_NCI-GLOSS:CDR0000597136 NCI:C16514 GO:GO:0006260 AOD:0000021657 NCI:C18125 MSH:D004261 CSP:2102-4830 CSP:3099-6564 CHV:0000004068 |
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| Definition |
A complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (DnaB or MCM complex) precedes the DNA synthetic machinery and unwinds the duplex parental DNA in cooperation with the SSB or RPA. On the leading strand, replication occurs continuously in a 5 to 3 direction, whereas on the lagging strand, DNA replication occurs discontinuously by synthesis and joining of short Okazaki fragments. In prokaryotes, the leading strand replication apparatus consists of a DNA polymerase (pol III core), a sliding clamp (beta), and a clamp loader (gamma delta complex). The DNA primase (DnaG) is needed to form RNA primers. Normally, during replication of the lagging-strand DNA template, an RNA primer is removed either by an RNase H or by the 5 to 3 exonuclease activity of DNA pol I, and the DNA ligase joins the Okazaki fragments. In eukaryotes, three DNA polymerases (alpha, delta, and epsilon) have been identified. DNA primase forms a permanent complex with DNA polymerase alpha. PCNA and RFC function as a clamp and a clamp loader. FEN 1 and RNase H1 remove the RNA from the Okazaki fragments and DNA ligase I joins the DNA. |
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| label |
DNA Replication |
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| MCID |
MC00183472 |
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| PMOID |
PMO:00014497 |
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| prefixIRI |
pmo:PMO_00014497 |
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| prefLabel |
DNA Replication |
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| Synonym |
Replication, DNA DNA Synthesis dna replications DNA replication (finding) DNA synthesis DNA replication deoxyribonucleic acid synthesis dna replication dna synthesis Deoxyribonucleic acid replication synthesis dna Replication Replications, DNA Deoxyribonucleic acid replication (finding) replication DNA biosynthesis DNA Replications |
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| Tree Number |
T4.5.5 |
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| subClassOf |