Physician Data Query

Last uploaded: August 28, 2024
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Preferred Name

levetiracetam
Synonyms

(S)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide

1-pyrrolidineacetamide, alpha-ethyl-2-oxo-,(S)-

Keppra
Definitions

A pyrrolidine with antiepileptic activity. The exact mechanism through which levetiracetam exerts its effects is unknown but does not involve inhibitory and excitatory neurotransmitter activity. Stereoselective binding of levetiracetam was confined to synaptic plasma membranes in the central nervous system with no binding occurring in peripheral tissue. Levetiracetam inhibits burst firing without affecting normal neuronal excitability, which suggests that it may selectively prevent hyper-synchronization of epileptiform burst firing and propagation of seizure activity. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47581" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47581" NCI Thesaurus)
ID

http://purl.bioontology.org/ontology/PDQ/CDR0000526173
altLabel

(S)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide

1-pyrrolidineacetamide, alpha-ethyl-2-oxo-,(S)-

Keppra
CAS Registry

102767-28-2
cui

C0377265

C0876060
DATE FIRST PUBLISHED

2006-12-18
definition

A pyrrolidine with antiepileptic activity. The exact mechanism through which levetiracetam exerts its effects is unknown but does not involve inhibitory and excitatory neurotransmitter activity. Stereoselective binding of levetiracetam was confined to synaptic plasma membranes in the central nervous system with no binding occurring in peripheral tissue. Levetiracetam inhibits burst firing without affecting normal neuronal excitability, which suggests that it may selectively prevent hyper-synchronization of epileptiform burst firing and propagation of seizure activity. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47581" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47581" NCI Thesaurus)
LT

TRD
NCI ID

C47581
notation

CDR0000526173
ORIG STY

Drug/agent
prefLabel

levetiracetam
tui

T109

T121
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Mapping To Ontology Source
http://purl.bioontology.org/ontology/NDFRT/N0000148644 NDFRT CUI
http://purl.bioontology.org/ontology/MESH/D000077287 MESH CUI
http://purl.bioontology.org/ontology/LNC/LP28566-5 LOINC CUI
http://purl.bioontology.org/ontology/SNOMEDCT/116076009 SNOMEDCT CUI
http://purl.bioontology.org/ontology/ATC/N03AX14 ATC CUI
http://purl.bioontology.org/ontology/MESH/D000077287 MESH CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387000003 SNOMEDCT CUI
http://purl.bioontology.org/ontology/VANDF/4021198 VANDF CUI
http://purl.bioontology.org/ontology/SCTSPA/387000003 SCTSPA CUI
http://purl.bioontology.org/ontology/NDDF/008058 NDDF CUI
http://purl.bioontology.org/ontology/SCTSPA/116076009 SCTSPA CUI
http://purl.bioontology.org/ontology/MSHFRE/D000077287 MSHFRE CUI
http://purl.bioontology.org/ontology/LNC/MTHU060540 LOINC CUI
http://purl.bioontology.org/ontology/RXNORM/114477 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/261547 RXNORM CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148644 NDFRT LOOM
http://purl.obolibrary.org/obo/NCIT_C47581 BERO LOOM
https://go.drugbank.com/drugs/DB01202 MDM LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#31886 OCHV LOOM
http://purl.bioontology.org/ontology/LNC/LP28566-5 LOINC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026566 PMAPP-PMO LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass961c0f62_7cdc_4fa3_868e_9435d1fe3e30 WWECA LOOM
http://purl.jp/bio/4/id/200906043074474621 IOBC LOOM
http://www.case.edu/EpSO.owl#Levetiracetam MEPO LOOM
http://purl.bioontology.org/ontology/ATC/N03AX14 ATC LOOM
http://purl.bioontology.org/ontology/MESH/D000077287 MESH LOOM
http://www.case.edu/EpilepsyOntology.owl#Levetiracetam EPSO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387000003 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/VANDF/4021198 VANDF LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass4bd070e8_58ba_4504_bbe6_ebad58f2d0ee WWECA LOOM
http://purl.obolibrary.org/obo/CHEBI_6437 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_6437 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_6437 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_6437 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_6437 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6437 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_6437 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_6437 ECTO LOOM
http://purl.obolibrary.org/obo/CHEBI_6437 EFO LOOM
https://bioportal.bioontology.org/ontologies/STMSO#Levetiracetam STMSO LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47581 NCIT LOOM
http://purl.bioontology.org/ontology/NDDF/008058 NDDF LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass701f0dcd_c177_4dce_9351_a82092676c88 WWECA LOOM
http://stirdf.jst.go.jp/id/200907009255998673 IOBC LOOM
http://www.drugbank.ca/drugs/DB01202 FTC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0377265 OCHV LOOM
http://purl.bioontology.org/ontology/CPT/80177 CPT LOOM
http://www.co-ode.org/ontologies/galen#Levetiracetam GALEN LOOM
http://purl.bioontology.org/ontology/LNC/MTHU060540 LOINC LOOM
http://purl.bioontology.org/ontology/RXNORM/114477 RXNORM LOOM