loading...| Preferred Name |
Scleroderma |
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| Synonyms |
Progressive Systemic Scleroderma Scleroderma Dermatosclerosis |
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| Definitions |
[HPO Definition]: A chronic autoimmune phenomenon characterized by fibrosis (or hardening) and vascular alterations of the skin. [HPO:sdoelken] [NCI-GLOSS Definition]: A chronic disorder marked by hardening and thickening of the skin. Scleroderma can be localized or it can affect the entire body (systemic). [NICHD Definition]: A chronic and progressive autoimmune disorder characterized by thickening of the skin and the connective tissues. [GARD Definition]: Scleroderma is a group of widespread connective tissue diseases that involve changes in the skin, blood vessels, muscles, and internal organs. There are two main types. Localized scleroderma affects only the skin. Systemic scleroderma affects the blood vessels and internal organs, as well as the skin. Although the cause of scleroderma is unknown, it is believed to be related to an overproduction and accumulation of collagen which results when the immune system turns against the body (autoimmune reaction). There is no cure, but various treatments can relieve symptoms. - this information is from GARD/ORDR/NCATS. [NCIt Definition]: A localized or systemic chronic and progressive autoimmune disorder characterized by thickening of the skin and the connective tissues. Localized scleroderma affects only the skin. Systemic scleroderma affects internal organs, including the heart, lungs, gastrointestinal tract, and kidneys. [CSP Definition]: Chronic hardening and thickening of the skin caused by swelling and thickening of fibrous tissue leading to eventual atrophy of the epidermis; can occur as a localized or a systemic disease. |
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| ID |
http://pat.nichd.nih.gov/maternalconditions/C0011644 |
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| Definition |
[HPO Definition]: A chronic autoimmune phenomenon characterized by fibrosis (or hardening) and vascular alterations of the skin. [HPO:sdoelken] [NCI-GLOSS Definition]: A chronic disorder marked by hardening and thickening of the skin. Scleroderma can be localized or it can affect the entire body (systemic). [NICHD Definition]: A chronic and progressive autoimmune disorder characterized by thickening of the skin and the connective tissues. [GARD Definition]: Scleroderma is a group of widespread connective tissue diseases that involve changes in the skin, blood vessels, muscles, and internal organs. There are two main types. Localized scleroderma affects only the skin. Systemic scleroderma affects the blood vessels and internal organs, as well as the skin. Although the cause of scleroderma is unknown, it is believed to be related to an overproduction and accumulation of collagen which results when the immune system turns against the body (autoimmune reaction). There is no cure, but various treatments can relieve symptoms. - this information is from GARD/ORDR/NCATS. [NCIt Definition]: A localized or systemic chronic and progressive autoimmune disorder characterized by thickening of the skin and the connective tissues. Localized scleroderma affects only the skin. Systemic scleroderma affects internal organs, including the heart, lungs, gastrointestinal tract, and kidneys. [CSP Definition]: Chronic hardening and thickening of the skin caused by swelling and thickening of fibrous tissue leading to eventual atrophy of the epidermis; can occur as a localized or a systemic disease. |
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| External Source | ||
| Label |
Scleroderma |
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| notation |
C0011644 |
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| PAT ID |
C0011644 |
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| prefLabel |
Scleroderma |
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| Sub Class Of | ||
| Synonyms |
Progressive Systemic Scleroderma Scleroderma Dermatosclerosis |