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Orphanet Rare Disease Ontology
Last uploaded:
December 4, 2024
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| Preferred Name | Histoplasmosis | |
| Synonyms |
Darling disease |
|
| Definitions |
A rare mycosis characterized by granulomatous inflammation primarily of the lung after inhalation of spores of <i>Histoplasma capsulatum</i>. The severity of clinical disease depends on the immune status of the individual and the size of the inoculum. In immunocompetent persons, the infection usually takes a self-limiting and asymptomatic or relatively mild, flu-like course. In immunocompromised patients, it can become progressive and disseminated, involving multiple organs and presenting with fever, pneumonia, hepatosplenomegaly, skin infiltrates, and endocarditis, among others. |
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| ID |
http://www.orpha.net/ORDO/Orphanet_390 |
|
| alternative_term |
Darling disease
|
|
| definition |
A rare mycosis characterized by granulomatous inflammation primarily of the lung after inhalation of spores of <i>Histoplasma capsulatum</i>. The severity of clinical disease depends on the immune status of the individual and the size of the inoculum. In immunocompetent persons, the infection usually takes a self-limiting and asymptomatic or relatively mild, flu-like course. In immunocompromised patients, it can become progressive and disseminated, involving multiple organs and presenting with fever, pneumonia, hepatosplenomegaly, skin infiltrates, and endocarditis, among others.
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| definition_citation |
Orphanet
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|
| expertlink |
https://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=en&Expert=390 |
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| hasDbXref |
ICD-10:B39.9 UMLS:C0019655 MedDRA:10020141 ICD-10:B39.5 ICD-10:B39.2 ICD-10:B39.3 ICD-10:B39.1 ICD-10:B39.4 MeSH:D006660 ICD-10:B39.0 ICD-11:1F2A
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|
| label |
Histoplasmosis
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|
| notation |
ORPHA:390
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| part_of | ||
| prefixIRI |
ORDO:Orphanet_390
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|
| prefLabel |
Histoplasmosis
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| treeView | ||
| subClassOf |
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