loading...| Preferred Name | endocrine system | |
| Synonyms |
systema endocrinum endocrine system endocrine glandular system |
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| Definitions |
Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity. |
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| ID |
http://purl.obolibrary.org/obo/UBERON_0000949 |
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| composed primarily of | ||
| existence ends during | ||
| existence ends during or before | ||
| external_definition |
Anatomical system containing glands which regulates bodily functions though the secretion of hormones.[AAO] |
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| has part | ||
| has_exact_synonym |
systema endocrinum endocrine system endocrine glandular system |
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| has_relational_adjective |
endocrine |
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| homology_notes |
Multicellular organisms have complex endocrine systems, allowing responses to environmental stimuli, regulation of development, reproduction, and homeostasis. Nuclear receptors (NRs), a metazoan-specific family of ligand-activated transcription factors, play central roles in endocrine responses, as intermediates between signaling molecules and target genes. The NR family includes ligand-bound and orphan receptors, that is, receptors with no known ligand or for which there is no ligand Pocket. Understanding NR evolution has been further improved by comparison of several completed genomes, particularly those of deuterostomes and ecdysozoans. In contrast, evolution of NR ligands is still much debated. One hypothesis proposes that several independent gains and losses of ligand-binding ability in NRs occurred in protostomes and deuterostomes. A second hypothesis, pertaining to the NR3 subfamily (vertebrate steroid hormone receptors and estrogen related receptor), proposes that before the divergence of protostomes and deuterostomes, there was an ancestral steroid receptor (AncSR) that was ligand-activated and that orphan receptors secondarily lost the ability to bind a ligand. (...) Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages (...).[well established][VHOG] |
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| id |
UBERON:0000949 |
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| in_subset |
http://purl.obolibrary.org/obo/uberon/core#efo_slim http://purl.obolibrary.org/obo/uberon/core#vertebrate_core |
|
| label |
endocrine system |
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| notation |
UBERON:0000949 |
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| prefLabel |
endocrine system |
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| 数据库_交叉_引用 |
http://linkedlifedata.com/resource/umls/id/C0014136 http://en.wikipedia.org/wiki/Endocrine_system http://www.snomedbrowser.com/Codes/Details/278876000 MESH:D004703 FMA:9668 EHDAA2:0002224 MA:0000012 ZFA:0001158 GAID:439 AAO:0010279 EMAPA:35306 TAO:0001158 XAO:0000158 FBbt:00005068 UMLS:C0014136 CALOHA:TS-1301 VHOG:0000098 EV:0100128 EFO:0002969 NCIT:C12705 |
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| 文本定义 |
Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity. |
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| 有_obo_命名空间 |
uberon |
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| disjointWith |
http://purl.obolibrary.org/obo/UBERON_0001033 http://purl.obolibrary.org/obo/UBERON_0000990 http://purl.obolibrary.org/obo/UBERON_0001434 http://purl.obolibrary.org/obo/UBERON_0004456 http://purl.obolibrary.org/obo/UBERON_0001016 http://purl.obolibrary.org/obo/UBERON_0002390 http://purl.obolibrary.org/obo/UBERON_0001008 http://purl.obolibrary.org/obo/UBERON_0001009 http://purl.obolibrary.org/obo/UBERON_0001007 http://purl.obolibrary.org/obo/UBERON_0001004 http://purl.obolibrary.org/obo/UBERON_0002330 |
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| subClassOf |