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NMDC Ontology
| Preferred Name | negative regulation of gene expression | |
| Synonyms |
gene silencing |
|
| Definitions |
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation. |
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| ID |
http://purl.obolibrary.org/obo/GO_0010629 |
|
| comment |
This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation.
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| alternative term |
gene silencing
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| causally upstream of | ||
| causally upstream of or within | ||
| definition |
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
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| has_obo_namespace |
biological_process
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| has_related_synonym |
gene silencing
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|
| id |
GO:0010629
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| label |
negative regulation of gene expression
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| negatively regulates | ||
| notation |
GO:0010629
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| precedes | ||
| prefLabel |
negative regulation of gene expression
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| regulates (processual) | ||
| term tracker item | ||
| subClassOf |
http://purl.obolibrary.org/obo/GO_0010558 |
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