Pick's disease, is a rare neurodegenerative disease that causes progressive destruction of nerve cells in the brain. Symptoms include loss of speech (aphasia), and dementia. While some of the symptoms can initially be alleviated, the disease progresses and patients often die within two to ten years. A defining characteristic of the disease is build up of tau proteins in neurons, accumulating into silver-staining, spherical aggregations known as "Pick bodies". While the term Pick's disease was once used to represent a class of clinical syndromes with symptoms attributable to frontal and temporal lobe dysfunction, it is now used among professionals to mean a specific pathology that is just one of the causes of frontotemporal lobar degeneration. Some people still use the term Pick's disease to mean the more general clinical syndrome of frontotemporal lobar degeneration, but this has previously led to confusion among both professionals and patients and so its use should be restricted to the specific pathological subtype described below. It is also known as Pick disease and PiD (not to be confused with Pelvic Inflammatory Disease (PID) or Parkinson's Disease (PD)). a clinical syndrome associated with shrinking of the frontal and temporal anterior lobes of the brain. Originally known as Pick’s disease, the name and classification of FTD has been a topic of discussion for over a century. The current designation of the syndrome groups together Pick’s disease, primary progressive aphasia, and semantic dementia as FTD. Some doctors propose adding corticobasal degeneration and progressive supranuclear palsy to FTD and calling the group Pick Complex. These designations will continue to be debated. As it is defined today, the symptoms of FTD fall into two clinical patterns that involve either (1) changes in behavior, or (2) problems with language. NIF-Dysfunction does not provide a definition for Picks disease. *** TO DO *** Picks disease should be made a subclass of frontotemporal dementia.

http://purl.obolibrary.org/obo/ND_0000140

NIF-Dysfunction does not provide a definition for Picks disease. *** TO DO *** Picks disease should be made a subclass of frontotemporal dementia.

http://ontology.neuinfo.org/NIF/Dysfunction/NIF-Dysfunction.owl#nlx_dys_090801

Alexander P. Cox

http://www.ninds.nih.gov/disorders/picks/picks.htm

http://en.wikipedia.org/wiki/Pick%27s_disease

Picks disease

ND:0000140

Picks disease

Pick's disease, is a rare neurodegenerative disease that causes progressive destruction of nerve cells in the brain. Symptoms include loss of speech (aphasia), and dementia. While some of the symptoms can initially be alleviated, the disease progresses and patients often die within two to ten years. A defining characteristic of the disease is build up of tau proteins in neurons, accumulating into silver-staining, spherical aggregations known as "Pick bodies". While the term Pick's disease was once used to represent a class of clinical syndromes with symptoms attributable to frontal and temporal lobe dysfunction, it is now used among professionals to mean a specific pathology that is just one of the causes of frontotemporal lobar degeneration. Some people still use the term Pick's disease to mean the more general clinical syndrome of frontotemporal lobar degeneration, but this has previously led to confusion among both professionals and patients and so its use should be restricted to the specific pathological subtype described below. It is also known as Pick disease and PiD (not to be confused with Pelvic Inflammatory Disease (PID) or Parkinson's Disease (PD)).

a clinical syndrome associated with shrinking of the frontal and temporal anterior lobes of the brain. Originally known as Pick’s disease, the name and classification of FTD has been a topic of discussion for over a century. The current designation of the syndrome groups together Pick’s disease, primary progressive aphasia, and semantic dementia as FTD. Some doctors propose adding corticobasal degeneration and progressive supranuclear palsy to FTD and calling the group Pick Complex. These designations will continue to be debated. As it is defined today, the symptoms of FTD fall into two clinical patterns that involve either (1) changes in behavior, or (2) problems with language.

http://purl.obolibrary.org/obo/ND_0000167