loading...| Preferred Name | Motor Neuron Disease | |
| Synonyms |
Motor System Disease |
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| Definitions |
Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy ( BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation (MeSH). |
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| ID |
http://uri.neuinfo.org/nif/nifstd/birnlex_12565 |
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| alternative label |
Motor System Disease |
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| createdDate |
2007-10-05 |
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| definingCitation |
Adams et al., Principles of Neurology, 6th ed, p1089 |
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| definingCitationURI |
http://www.ninds.nih.gov/disorders/motor_neuron_diseases/motor_neuron_diseases.htm |
|
| definition |
Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy ( BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation (MeSH). |
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| editorial note | ||
| externalSourceId |
C0085084 D016472 _8.3_2.5 |
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| hasBirnlexCurator | ||
| hasCurationStatus | ||
| hasDefinitionSource | ||
| hasExternalSource | ||
| label |
Motor Neuron Disease |
|
| MeshUid |
D016472 |
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| modifiedDate |
2007-11-18 |
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| nifID |
_8.3_2.5 |
|
| note |
Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy ( BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation (MeSH). |
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| preferred label |
Motor Neuron Disease |
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| Resource Identifier |
C0085084 D016472 _8.3_2.5 |
|
| synonym |
Motor System Disease |
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| UmlsCui |
C0085084 |
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| usageNote |
Note that MeSH includes the following sub-types which cannot easily be specified as subtypes without leading to multiple inheritance (e.g., Anterior Horn Cell Disease; Familial Motor Neuron Disease; Lateral Sclerosis; Lower Motor Neuron Disease; Upper Motor Neuron Disease; Primary Lateral Sclerosis; Secondary Motor Neuron Disease). These subtypes describe either the location within the CNS axis where motor neuron degeneration is observed, the complex temporal development of that degeneration, and the hereditory nature of the disorder. In the course of many specific patient cases, the location of degenerating MNs starts in one location and then procedes to others, as is the case for some of the concrete child classess created for this parent class. In the end, a more detailed OWL representation would need to be employed where the location, timing, and putative casue of degenerating MNs is specified using ObjectProperties, and such subtypes as LOWER MOTOR NEURON DISEASE would then be inferred types. The practical problem with this approach is that terms such as ALS and LOWER MN DISEASE have a particular meaning in a clinical context. Though ALS might be inferred to be a member of the set of LOWER MN DISEASEs, since there is loss of MNs in the lower spinal cord, clinicians typically consider LOWER MN DISEASE to have a distinct set of presenting signs when compared to ALS. Clinicians do not typically consider ALS to be a type of LOWER MN DISEASE (BB: 2007-10-05) |
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| subClassOf |
http://uri.neuinfo.org/nif/nifstd/birnlex_11013 http://purl.obolibrary.org/obo/DOID_1289 |