loading...| Preferred Name |
testosterone |
|
| Synonyms |
17beta-hydroxyandrost-4-en-3-one TESTOSTERONE Testosterone testosterone 4-androsten-17beta-ol-3-one 17beta-Hydroxy-4-androsten-3-one 17beta-hydroxy-4-androsten-3-one Androderm testosteronum Testosteron testosterona Andronaq Testosterone Enanthate Android 25 Testosteroid Testoviron Schering Testiculosterone Trans-Testosterone Delatestryl Everone 200 Testred Cypionate 200 Cristerone T Testrone Sustason 250 Perandren Androlin Neotestis Testogel Percutacrine Androgenique Malogen Testoviron Homosteron Teslen Depo-Testosterone Andronate 100 Scheinpharm Testone-Cyp Virormone Testosterone Hydrate Metandren Depotest Orquisteron Sustanone Testim Android 10 Testro Aq Andropatch Testoviron T Andronate 200 Relibra Synandrol F Cristerona T Testolin TES Sustanon Beta Testosterone Testoderm Tts Delatest Testobase Methyltestosterone Testryl Testostosterone Andro 100 CDB 111C Mertestate Neo-Testis Andriol Depo-Testosterone Cypionate Oreton F Testamone 100 Testred Striant Virosterone Testosterona (INN-Spanish) Andro Malogen in Oil Oreton T-Cypionate Oreton-F Malestrone Testoject-50 Homosterone Aquaspension Injection Testandrone Neo-Hombreol F Primoteston Virilon IM Libigel Oreton Methyl Andryl 200 Primotest Testoderm Testaqua Andrusol Testosterone Cypionate Geno-Cristaux Gremy Virilon Andro L Androgel Testopel Pellets Testopropon Malerone Testosteronum (INN-Latin) Andropository 200 Androsorb Testrin-P Android 5 |
|
| Definitions |
A potent androgenic steroid and major product secreted by the leydig cells of the testis. Its production is stimulated by luteinizing hormone from the pituitary gland. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to dihydrotestosterone or estradiol. (PubChem) Pharmacology: Testosterone is a steroid hormone from the androgen group. Testosterone is primarily secreted in the testes of males and the ovaries of females although small amounts are secreted by the adrenal glands. It is the principal male sex hormone and an anabolic steroid. In both males and females, it plays key roles in health and well-being. Examples include enhanced libido, energy, immune function, and protection against osteoporosis. On average, the adult male body produces about twenty times the amount of testosterone than an adult female's body does. Mechanism of action: The effects of testosterone in humans and other vertebrates occur by way of two main mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors. Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5-reductase. DHT binds to the same androgen receptor even more strongly than T, so that its androgenic potency is about 2.5 times that of T. The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects. Drug type: Approved. Investigational. Small Molecule. Drug category: Androgens Street names: Dea No. 4000, A, 200 An androstanoid having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5.. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_17347 |
|
| comment |
Street names: Dea No. 4000, A, 200 |
|
| charge |
0 |
|
| createdDate |
March 5, 2010 |
|
| database_cross_reference |
KEGG:D00075 KNApSAcK:C00003675 HMDB:HMDB0000234 PMID:24498482 PMID:18900503 PDBeChem:TES Wikipedia:Testosterone Reaxys:1915399 Beilstein:1915399 KEGG:C00535 DrugBank:DB00624 Beilstein:3653705 PMID:10438974 PMID:11786693 Drug_Central:2607 Gmelin:538843 LIPID_MAPS_instance:LMST02020002 CAS:58-22-0 |
|
| definition |
A potent androgenic steroid and major product secreted by the leydig cells of the testis. Its production is stimulated by luteinizing hormone from the pituitary gland. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to dihydrotestosterone or estradiol. (PubChem) Pharmacology: Testosterone is a steroid hormone from the androgen group. Testosterone is primarily secreted in the testes of males and the ovaries of females although small amounts are secreted by the adrenal glands. It is the principal male sex hormone and an anabolic steroid. In both males and females, it plays key roles in health and well-being. Examples include enhanced libido, energy, immune function, and protection against osteoporosis. On average, the adult male body produces about twenty times the amount of testosterone than an adult female's body does. Mechanism of action: The effects of testosterone in humans and other vertebrates occur by way of two main mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors. Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5-reductase. DHT binds to the same androgen receptor even more strongly than T, so that its androgenic potency is about 2.5 times that of T. The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects. Drug type: Approved. Investigational. Small Molecule. Drug category: Androgens |
|
| formula |
C19H28O2 |
|
| has characteristic | ||
| has exact synonym |
17beta-hydroxyandrost-4-en-3-one TESTOSTERONE Testosterone testosterone |
|
| has role |
http://purl.obolibrary.org/obo/CHEBI_83056 http://purl.obolibrary.org/obo/CHEBI_77746 |
|
| has_alternative_id |
CHEBI:45798 CHEBI:15214 CHEBI:26883 CHEBI:9461 |
|
| has_obo_namespace |
chebi_ontology |
|
| has_related_synonym |
4-androsten-17beta-ol-3-one 17beta-Hydroxy-4-androsten-3-one 17beta-hydroxy-4-androsten-3-one Androderm testosteronum Testosteron testosterone testosterona |
|
| hasExternalSource |
DB00624 |
|
| hasStreetName |
DEA No. 4000 |
|
| id |
CHEBI:17347 |
|
| in_subset | ||
| inchi |
InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 |
|
| inchikey |
MUMGGOZAMZWBJJ-DYKIIFRCSA-N |
|
| label |
testosterone |
|
| mass |
288.42440 |
|
| modifiedDate |
June 30, 2010 |
|
| monoisotopicmass |
288.20893 |
|
| notation |
CHEBI:17347 |
|
| prefLabel |
testosterone |
|
| smiles |
[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@@H](O)CC[C@@]21[H] |
|
| synonym |
Andronaq Testosterone Enanthate Android 25 Testosteroid Testoviron Schering Testiculosterone Trans-Testosterone Delatestryl Everone 200 Testred Cypionate 200 Cristerone T Testrone Sustason 250 Perandren Androlin Neotestis Testogel Percutacrine Androgenique Malogen Testoviron Homosteron Teslen Depo-Testosterone Andronate 100 Scheinpharm Testone-Cyp Virormone Testosterone Hydrate Metandren Depotest Orquisteron Sustanone Testim Android 10 Testro Aq Andropatch Testoviron T Andronate 200 Relibra Synandrol F Cristerona T Testolin TES Sustanon Beta Testosterone Testoderm Tts Delatest Testobase Methyltestosterone Testryl Testostosterone Andro 100 CDB 111C Mertestate Neo-Testis Andriol Depo-Testosterone Cypionate Oreton F Testamone 100 Testred Striant Virosterone Testosterona (INN-Spanish) Andro Malogen in Oil Oreton T-Cypionate Oreton-F Malestrone Testoject-50 Homosterone Aquaspension Injection Testandrone Neo-Hombreol F Primoteston Virilon IM Libigel Oreton Methyl Andryl 200 Primotest Testoderm Testaqua Andrusol Testosterone Cypionate Geno-Cristaux Gremy Virilon Andro L Androgel Testopel Pellets Testopropon Malerone Testosteronum (INN-Latin) Andropository 200 Androsorb Testrin-P Android 5 |
|
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_50402 http://purl.obolibrary.org/obo/BFO_0000004 http://purl.obolibrary.org/obo/CHEBI_35343 http://uri.neuinfo.org/nif/nifstd/nlx_chem_1003011 |