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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Quetiapine | |
| Synonyms |
QUETIAPINE Quetiapine |
|
| Definitions |
A dibenzothiazepine derivative with antipsychotic property. Quetiapine fumarate antagonizes serotonin activity mediated by 5-HT 1A and 5-HT2 receptors. With a lower affinity, this agent also reversibly binds to dopamine D1 and D2 receptors in the mesolimbic and mesocortical areas of the brain leading to decreased psychotic effects, such as hallucinations and delusions. In addition, quetiapine also binds to other alpha-1, alpha-2 adrenergic and histamine H1 receptors. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61917 |
|
| CAS_Registry |
111974-69-7
|
|
| CHEBI_ID |
CHEBI:8707
|
|
| Chemical_Formula |
C21H25N3O2S
|
|
| code |
C61917
|
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA
|
|
| DEFINITION |
A dibenzothiazepine derivative with antipsychotic property. Quetiapine fumarate antagonizes serotonin activity mediated by 5-HT 1A and 5-HT2 receptors. With a lower affinity, this agent also reversibly binds to dopamine D1 and D2 receptors in the mesolimbic and mesocortical areas of the brain leading to decreased psychotic effects, such as hallucinations and delusions. In addition, quetiapine also binds to other alpha-1, alpha-2 adrenergic and histamine H1 receptors.
|
|
| FDA_UNII_Code |
BGL0JSY5SI
|
|
| FULL_SYN |
QUETIAPINE Quetiapine
|
|
| Has_Salt_Form | ||
| label |
Quetiapine
|
|
| Legacy Concept Name |
Quetiapine
|
|
| Preferred_Name |
Quetiapine
|
|
| prefixIRI |
Thesaurus:C61917
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C0123091
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|
| subClassOf |
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