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National Cancer Institute Thesaurus
| Preferred Name | Escitalopram | |
| Synonyms |
escitalopram ESCITALOPRAM S(+)-Citalopram (S)-Citalopram Escitalopram Seroplex |
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| Definitions |
The active S-stereoisomer of the selective serotonin reuptake inhibitor (SSRI) citalopram with antidepressant, anti-obsessive-compulsive and antibulimic properties. Escitalopram inhibits the reuptake of the neurotransmitter serotonin (5-HT) at the serotonin reuptake pump of the neuronal membrane of the presynaptic cell, thereby increasing levels of 5-HT within the synaptic cleft and enhancing the actions of serotonin on 5HT1A autoreceptors. Unlike other SSRIs, escitalopram appears to not only bind to a primary high-affinity site on the serotonin transporter protein but also to a secondary lower-affinity allosteric site that is considered to stabilize and prolong drug binding. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61754 |
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| ALT_DEFINITION |
A drug used to treat depression and certain anxiety disorders. It belongs to the family of drugs called selective serotonin reuptake inhibitors (SSRIs).
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| CAS_Registry |
128196-01-0
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| CHEBI_ID |
CHEBI:36791
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| Chemical_Formula |
C20H21FN2O
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| code |
C61754
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
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| Contributing_Source |
CTRP FDA
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| DEFINITION |
The active S-stereoisomer of the selective serotonin reuptake inhibitor (SSRI) citalopram with antidepressant, anti-obsessive-compulsive and antibulimic properties. Escitalopram inhibits the reuptake of the neurotransmitter serotonin (5-HT) at the serotonin reuptake pump of the neuronal membrane of the presynaptic cell, thereby increasing levels of 5-HT within the synaptic cleft and enhancing the actions of serotonin on 5HT1A autoreceptors. Unlike other SSRIs, escitalopram appears to not only bind to a primary high-affinity site on the serotonin transporter protein but also to a secondary lower-affinity allosteric site that is considered to stabilize and prolong drug binding.
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| Display_Name |
Escitalopram
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| FDA_UNII_Code |
4O4S742ANY
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| FULL_SYN |
escitalopram ESCITALOPRAM S(+)-Citalopram (S)-Citalopram Escitalopram Seroplex
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| Has_Salt_Form | ||
| Has_Target | ||
| label |
Escitalopram
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| Legacy Concept Name |
Escitalopram
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| Preferred_Name |
Escitalopram
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| prefixIRI |
Thesaurus:C61754
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| Semantic_Type |
Pharmacologic Substance
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| UMLS_CUI |
C1099456
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| subClassOf |
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