loading...| Preferred Name | Isotretinoin | |
| Synonyms |
Neovitamin A 13-cis retinoic acid Isotretinoinum 13-cis-Retinoic Acid 13-cis-Vitamin A Acid ISOTRETINOIN 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-cis-4-trans-6-trans-8-trans-nonatetraenoic Acid Isotretinoin 13-cis-Retinoate cis-Retinoic Acid Retinoicacid-13-cis Neovitamin A Acid isotretinoin 13-cRA Absorica Accure Accutane Amnesteem Cistane Claravis Isotrex Isotrexin Myorisan Oratane Ro 4-3780 Ro-4-3780 Roaccutan Roaccutane Roacutan Sotret ZENATANE |
|
| Definitions |
A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C603 |
|
| Accepted_Therapeutic_Use_For |
Severe recalcitrant nodular acne; psoriasis; cornification disorders; cutaneous T-cell lymphoma; juvenile metastatic neuroblastoma and leukemia |
|
| ALT_DEFINITION |
A drug that is used in the treatment of acne and psoriasis and is being studied in cancer prevention. It is a type of retinoid. |
|
| CAS_Registry |
4759-48-2 |
|
| CHEBI_ID |
CHEBI:6067 |
|
| Chemical_Formula |
C20H28O2 |
|
| code |
C603 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc |
|
| DEFINITION |
A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization. |
|
| Display_Name |
Isotretinoin |
|
| FDA_UNII_Code |
EH28UP18IF |
|
| FULL_SYN |
Neovitamin A 13-cis retinoic acid Isotretinoinum 13-cis-Retinoic Acid 13-cis-Vitamin A Acid ISOTRETINOIN 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-cis-4-trans-6-trans-8-trans-nonatetraenoic Acid Isotretinoin 13-cis-Retinoate cis-Retinoic Acid Retinoicacid-13-cis Neovitamin A Acid isotretinoin 13-cRA Absorica Accure Accutane Amnesteem Cistane Claravis Isotrex Isotrexin Myorisan Oratane Ro 4-3780 Ro-4-3780 Roaccutan Roaccutane Roacutan Sotret ZENATANE |
|
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Isotretinoin |
|
| Legacy Concept Name |
Isotretinoin |
|
| Maps_To |
Isotretinoin |
|
| NCI_Drug_Dictionary_ID |
42657 |
|
| NSC Number |
329481 |
|
| PDQ_Closed_Trial_Search_ID |
42657 |
|
| PDQ_Open_Trial_Search_ID |
42657 |
|
| Preferred_Name |
Isotretinoin |
|
| prefixIRI |
Thesaurus:C603 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0022265 |
|
| subClassOf |