loading...| Preferred Name |
Retinoic Acid Agent |
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| Synonyms |
Retinoic Acid and Derivatives Retinoic Acids Retinoic Acid Agent Retinoid Retinoids retinoid |
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| Definitions |
A group of agents that includes retinol (Vitamin A) and related compounds with potential antineoplastic and/or chemopreventive activities. A retinoic acid agent binds to and/or activates specific nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs), thereby modulating transcription of genes responsible for cell differentiation and proliferation. A retinoic acid agent may exhibit immunomodulatory and anti-inflammatory properties and may inhibit ornithine decarboxylase, resulting in a decrease in polyamine synthesis and keratinization. (NCI04) |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C804 |
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| ALT_DEFINITION |
A nutrient that the body needs in small amounts to function and stay healthy. Retinoic acid is made in the body from vitamin A and helps cells to grow and develop, especially in the embryo. A form of retinoic acid made in the laboratory is put on the skin to treat conditions such as acne and is taken by mouth to treat acute promyelocytic leukemia (a fast-growing cancer in which there are too many immature blood-forming cells in the blood and bone marrow). Retinoic acid is being studied in the prevention and treatment of other types of cancer. |
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| CHEBI_ID |
CHEBI:26537 |
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| code |
C804 |
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| DEFINITION |
A group of agents that includes retinol (Vitamin A) and related compounds with potential antineoplastic and/or chemopreventive activities. A retinoic acid agent binds to and/or activates specific nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs), thereby modulating transcription of genes responsible for cell differentiation and proliferation. A retinoic acid agent may exhibit immunomodulatory and anti-inflammatory properties and may inhibit ornithine decarboxylase, resulting in a decrease in polyamine synthesis and keratinization. (NCI04) |
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| FULL_SYN |
Retinoic Acid and Derivatives Retinoic Acids Retinoic Acid Agent Retinoid Retinoids retinoid |
|
| label |
Retinoic Acid Agent |
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| Legacy Concept Name |
Retinoic_Acid_Agent |
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| Preferred_Name |
Retinoic Acid Agent |
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| prefixIRI |
Thesaurus:C804 |
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| Semantic_Type |
Classification |
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| UMLS_CUI |
C0035339 |
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| subClassOf |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1934 |