loading...| Preferred Name |
Gastrointestinal Stromal Tumor |
|
| Synonyms |
Gastrointestinal stromal tumor Gastrointestinal Stromal Tumor Gastrointestinal Stromal Neoplasm Gastrointestinal stromal tumor, unspecified site Gastrointestinal stromal tumor, NOS Gastrointestinal Stromal Tumor (GIST) gastrointestinal stromal tumor GIST GIST, NOS GISTs |
|
| Definitions |
A stromal tumor most commonly seen in the gastrointestinal tract. Rare cases of solitary masses in the omentum or the mesentery have also been reported (extragastrointestinal gastrointestinal stromal tumor). It is a tumor that differentiates along the lines of interstitial cells of Cajal. Most cases contain KIT- or PDGFRA-activating mutations. Until recently, surgery has been the only effective therapy for this tumor. However, many patients still experience recurrence. Conventional chemotherapy and radiation therapy have been of limited value. A KIT tyrosine kinase inhibitor, imatinib mesylate (also known as STI-571 or Gleevec), is now effective in the treatment of relapsed and unresectable cases. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C3868 |
|
| ALT_DEFINITION |
A type of tumor that usually begins in cells in the wall of the gastrointestinal tract. It can be benign or malignant. |
|
| code |
C3868 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C138190 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C156952 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168661 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168656 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168662 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C175325 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C156966 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168658 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C193248 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192842 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C126659 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118168 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C165258 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C193178 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C102905 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C193231 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C193006 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C103117 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C168655 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C138188 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C158520 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C193249 |
|
| Contributing_Source |
Cellosaurus CPTAC CTEP CTRP GDC mCode |
|
| DEFINITION |
A stromal tumor most commonly seen in the gastrointestinal tract. Rare cases of solitary masses in the omentum or the mesentery have also been reported (extragastrointestinal gastrointestinal stromal tumor). It is a tumor that differentiates along the lines of interstitial cells of Cajal. Most cases contain KIT- or PDGFRA-activating mutations. Until recently, surgery has been the only effective therapy for this tumor. However, many patients still experience recurrence. Conventional chemotherapy and radiation therapy have been of limited value. A KIT tyrosine kinase inhibitor, imatinib mesylate (also known as STI-571 or Gleevec), is now effective in the treatment of relapsed and unresectable cases. |
|
| Display_Name |
Gastrointestinal Stromal Tumor |
|
| FULL_SYN |
Gastrointestinal stromal tumor Gastrointestinal Stromal Tumor Gastrointestinal Stromal Neoplasm Gastrointestinal stromal tumor, unspecified site Gastrointestinal stromal tumor, NOS Gastrointestinal Stromal Tumor (GIST) gastrointestinal stromal tumor GIST GIST, NOS GISTs |
|
| ICD-O-3_Code |
8936/1 |
|
| Is_Value_For_GDC_Property | ||
| label |
Gastrointestinal Stromal Tumor |
|
| Legacy Concept Name |
Gastrointestinal_Stromal_Tumor |
|
| Maps_To |
Gastrointestinal stromal tumor, NOS 8936/1 GIST, NOS |
|
| Neoplasm_Has_Special_Category | ||
| Neoplastic_Status |
Undetermined |
|
| Preferred_Name |
Gastrointestinal Stromal Tumor |
|
| prefixIRI |
Thesaurus:C3868 |
|
| Semantic_Type |
Neoplastic Process |
|
| UMLS_CUI |
C3149028 |
|
| subClassOf |