National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Hemophagocytic Lymphohistiocytosis
Synonyms

hemophagocytic lymphohistiocytosis

Hemophagocytic Lymphohistiocytosis

Hemophagocytic Disorder

HLH

Definitions

A rare, but potentially life-threatening disorder, characterized by the proliferation of histiocytes and macrophages, and phagocytosis of red blood cells, white blood cells, and platelets. It may be inherited or secondary due to infections, autoimmune disorders, or underlying malignancies. Signs and symptoms include fever, lymphadenopathy, hepatomegaly, splenomegaly, and pancytopenia.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C34792

ALT_DEFINITION

A rare disorder in which histiocytes and lymphocytes (types of white blood cells) build up in organs including the skin, spleen, and liver, and destroy other blood cells. Hemophagocytic lymphohistiocytosis may be inherited or caused by certain conditions or diseases, including infections, immunodeficiency (inability of the body to fight infections), and cancer.

code

C34792

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C118168

Contributing_Source

CTRP

DEFINITION

A rare, but potentially life-threatening disorder, characterized by the proliferation of histiocytes and macrophages, and phagocytosis of red blood cells, white blood cells, and platelets. It may be inherited or secondary due to infections, autoimmune disorders, or underlying malignancies. Signs and symptoms include fever, lymphadenopathy, hepatomegaly, splenomegaly, and pancytopenia.

Display_Name

Hemophagocytic Lymphohistiocytosis

FULL_SYN

hemophagocytic lymphohistiocytosis

Hemophagocytic Lymphohistiocytosis

Hemophagocytic Disorder

HLH

label

Hemophagocytic Lymphohistiocytosis

Legacy Concept Name

Hemophagocytic_Lymphohistiocytosis

Maps_To

Haemophagocytic lymphohistiocytosis

Preferred_Name

Hemophagocytic Lymphohistiocytosis

prefixIRI

Thesaurus:C34792

Semantic_Type

Disease or Syndrome

UMLS_CUI

C3554542

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26324

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C203422

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C53543

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