loading...| Preferred Name |
Camptothecin |
|
| Synonyms |
(S)-4-ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolozino[1,2-b]quinoline-3,14(4H,12H)-dione CAMPTOTHECIN 1H-Pyrano[3',3'.6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4hydroxy-(S)-(9CI) 21, 22-Secocamptothecin-21-oic acid lactone (+)-Camptothecin 20-(S)-camptothecine Camptothecin camptothecin camptothecine 21, 22-secocamptothecin-21-oic acid lactone 20(S)-Camptothecine |
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| Definitions |
An alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. (NCI) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C338 |
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| ALT_DEFINITION |
An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors. |
|
| CAS_Registry |
7689-03-4 |
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| CHEBI_ID |
CHEBI:27656 |
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| Chemical_Formula |
C20H16N2O4 |
|
| code |
C338 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
FDA GDC |
|
| DEFINITION |
An alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. (NCI) |
|
| FDA_UNII_Code |
XT3Z54Z28A |
|
| FULL_SYN |
(S)-4-ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolozino[1,2-b]quinoline-3,14(4H,12H)-dione CAMPTOTHECIN 1H-Pyrano[3',3'.6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4hydroxy-(S)-(9CI) 21, 22-Secocamptothecin-21-oic acid lactone (+)-Camptothecin 20-(S)-camptothecine Camptothecin camptothecin camptothecine 21, 22-secocamptothecin-21-oic acid lactone 20(S)-Camptothecine |
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| Has_Salt_Form | ||
| Is_Value_For_GDC_Property | ||
| label |
Camptothecin |
|
| Legacy Concept Name |
Camptothecin |
|
| Maps_To |
Camptothecin |
|
| NCI_Drug_Dictionary_ID |
39173 |
|
| NSC Number |
94600 |
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| PDQ_Closed_Trial_Search_ID |
39173 |
|
| PDQ_Open_Trial_Search_ID |
39173 |
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| Preferred_Name |
Camptothecin |
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| prefixIRI |
Thesaurus:C338 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0006812 |
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| subClassOf |