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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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Preferred Name | Topoisomerase-I Inhibitor | |
Synonyms |
Topoisomerase-I Inhibitor Topoisomerase-I Inhibitors |
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Definitions |
Any substance that inhibits topoisomerase-I, a topoisomerase that relieves torsional stress in a DNA molecule by cutting only one strand of the DNA double helix. Inhibition of topoisomerase-I causes DNA damage, inhibition of DNA replication, and apoptosis. |
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ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1904 |
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CHEBI_ID |
CHEBI:50276
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code |
C1904
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Concept_In_Subset | ||
Contributing_Source |
CTRP
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DEFINITION |
Any substance that inhibits topoisomerase-I, a topoisomerase that relieves torsional stress in a DNA molecule by cutting only one strand of the DNA double helix. Inhibition of topoisomerase-I causes DNA damage, inhibition of DNA replication, and apoptosis.
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Display_Name |
Topoisomerase-I Inhibitor
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FULL_SYN |
Topoisomerase-I Inhibitor Topoisomerase-I Inhibitors
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label |
Topoisomerase-I Inhibitor
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Legacy Concept Name |
Topoisomerase-I_Inhibitor
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Preferred_Name |
Topoisomerase-I Inhibitor
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prefixIRI |
Thesaurus:C1904
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Semantic_Type |
Chemical Viewed Functionally
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UMLS_CUI |
C0594374
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subClassOf |
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Mapping To | Ontology | Source |
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http://purl.bioontology.org/ontology/npo#NPO_864 | NPO | LOOM |
http://purl.obolibrary.org/obo/CHEBI_50276 | DINTO | LOOM |
http://purl.obolibrary.org/obo/CHEBI_50276 | BIOMODELS | LOOM |
http://purl.obolibrary.org/obo/CHEBI_50276 | CHIRO | LOOM |
http://purl.obolibrary.org/obo/NCIT_C1904 | BERO | LOOM |