loading...| Preferred Name |
Topoisomerase-I Inhibitor |
|
| Synonyms |
Topoisomerase-I Inhibitor Topoisomerase-I Inhibitors |
|
| Definitions |
Any substance that inhibits topoisomerase-I, a topoisomerase that relieves torsional stress in a DNA molecule by cutting only one strand of the DNA double helix. Inhibition of topoisomerase-I causes DNA damage, inhibition of DNA replication, and apoptosis. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1904 |
|
| CHEBI_ID |
CHEBI:50276 |
|
| code |
C1904 |
|
| Concept_In_Subset | ||
| Contributing_Source |
CTRP |
|
| DEFINITION |
Any substance that inhibits topoisomerase-I, a topoisomerase that relieves torsional stress in a DNA molecule by cutting only one strand of the DNA double helix. Inhibition of topoisomerase-I causes DNA damage, inhibition of DNA replication, and apoptosis. |
|
| Display_Name |
Topoisomerase-I Inhibitor |
|
| FULL_SYN |
Topoisomerase-I Inhibitor Topoisomerase-I Inhibitors |
|
| label |
Topoisomerase-I Inhibitor |
|
| Legacy Concept Name |
Topoisomerase-I_Inhibitor |
|
| Preferred_Name |
Topoisomerase-I Inhibitor |
|
| prefixIRI |
Thesaurus:C1904 |
|
| Semantic_Type |
Chemical Viewed Functionally |
|
| UMLS_CUI |
C0594374 |
|
| subClassOf |
| Delete | Mapping To | Ontology | Source |
|---|---|---|---|
| http://purl.bioontology.org/ontology/npo#NPO_864 | NPO | LOOM | |
| http://purl.obolibrary.org/obo/CHEBI_50276 | DINTO | LOOM | |
| http://purl.obolibrary.org/obo/CHEBI_50276 | BIOMODELS | LOOM | |
| http://purl.obolibrary.org/obo/CHEBI_50276 | CHIRO | LOOM | |
| http://purl.obolibrary.org/obo/NCIT_C1904 | BERO | LOOM |