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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Insulin | |
| Synonyms |
INS INSULIN Insulin insulin |
|
| Definitions |
Insulin (51 aa, ~6 kDa) is encoded by the human INS gene. This protein is involved in the direct regulation of glucose metabolism. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2271 |
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| ALT_DEFINITION |
An antigen encoded by the INS gene and regulates glucose metabolism. It can be considered as an autoantigen and is commonly associated with autoimmune diabetes mellitus.
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|
| code |
C2271
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|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66830 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61410 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142800 |
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| Contributing_Source |
CDISC CTRP
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| DEFINITION |
Insulin (51 aa, ~6 kDa) is encoded by the human INS gene. This protein is involved in the direct regulation of glucose metabolism.
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| DesignNote |
Binding of insulin to its receptor stimulates glucose uptake, accelerates both glycolysis and the pentose phosphate cycle and increases glycogen synthesis in the liver. Insulin regulates protein and lipid metabolism. It also decreases blood glucose concentration by shuttling molecules into cells to be used for energy. Insulin is a cytosolic protein consisting of heterodimer of disulfide-linked alpha and beta chains generated after proteolytic release of an internal fragment, C-peptide, from proinsulin. This protein is produced in pancreatic islet beta cells.
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| Display_Name |
Insulin
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|
| FULL_SYN |
INS INSULIN Insulin insulin
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|
| label |
Insulin
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|
| Legacy Concept Name |
Insulin
|
|
| NCI_META_CUI |
CL026873
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|
| OMIM_Number |
176730
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|
| Preferred_Name |
Insulin
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|
| prefixIRI |
Thesaurus:C2271
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|
| Semantic_Type |
Amino Acid, Peptide, or Protein Hormone
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| Swiss_Prot |
P01308
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|
| subClassOf |
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