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National Cancer Institute Thesaurus
Last uploaded:
February 23, 2024
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| Preferred Name | Apoptosis | |
| Synonyms |
Programmed Cell Death programmed cell death Apoptotic Process APOPTOSIS Apoptosis PCD apoptosis |
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| Definitions |
A form of programmed cell death that begins when a cell receives internal or external signals, then proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopods, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing, and ends with the death of the cell. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17557 |
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| ALT_DEFINITION |
A form of programmed cell death triggered by internal or external signals that results in a series of characteristic morphological changes. A type of cell death in which a series of molecular steps in a cell leads to its death. This is the body's normal way of getting rid of unneeded or abnormal cells. The process of programmed cell death may be blocked in cancer cells.
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| code |
C17557
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C77526 |
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| Contributing_Source |
CDISC
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| DEFINITION |
A form of programmed cell death that begins when a cell receives internal or external signals, then proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopods, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing, and ends with the death of the cell.
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| DesignNote |
Important in ontogenesis, tumorigenesis, tissue turnover, lymphocyte selection and function and hormone-induced atrophy.
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| FULL_SYN |
Programmed Cell Death programmed cell death Apoptotic Process APOPTOSIS Apoptosis PCD apoptosis
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| label |
Apoptosis
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| Legacy Concept Name |
Apoptosis
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| Preferred_Name |
Apoptosis
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| prefixIRI |
Thesaurus:C17557
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| Semantic_Type |
Phenomenon or Process
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| UMLS_CUI |
C0162638
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| subClassOf |
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