loading...| Preferred Name | Natural Killer Cell | |
| Synonyms |
Killer Cells killer cell NATURAL KILLER CELL Killer Cell Natural Killer Cell natural killer cell NK NK Cell NK Cells NK cell NK-Cell NK-LGL |
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| Definitions |
Natural killer cells are cells that resemble large granular lymphocytes. They do not express markers of either T or B cell lineage. They are positive for CD16, CD56, and CD 94. These cells do possess Fc receptors for IgG and can kill target cells using antibody-dependent cell-mediated cytotoxicity. They can also use perforin to kill cells in the absence of antibody and killing may occur without previous sensitization. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C12536 |
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| ALT_DEFINITION |
A type of immune cell that has granules (small particles) with enzymes that can kill tumor cells or cells infected with a virus. A natural killer cell is a type of white blood cell. Cells resembling large granular lymphocytes that do not express markers of either T or B cell lineage. These cells express Fc receptors for IgG and can kill target cells using antibody-dependent cell-mediated cytotoxicity. They can also use perforin to kill cells in the absence of antibody, and may occur without previous sensitization. |
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| code |
C12536 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66830 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C78734 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61410 |
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| Contributing_Source |
CDISC CTRP |
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| DEFINITION |
Natural killer cells are cells that resemble large granular lymphocytes. They do not express markers of either T or B cell lineage. They are positive for CD16, CD56, and CD 94. These cells do possess Fc receptors for IgG and can kill target cells using antibody-dependent cell-mediated cytotoxicity. They can also use perforin to kill cells in the absence of antibody and killing may occur without previous sensitization. |
|
| Display_Name |
Natural Killer Cell |
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| FULL_SYN |
Killer Cells killer cell NATURAL KILLER CELL Killer Cell Natural Killer Cell natural killer cell NK NK Cell NK Cells NK cell NK-Cell NK-LGL |
|
| label |
Natural Killer Cell |
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| Legacy Concept Name |
Natural_Killer_Cell |
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| Preferred_Name |
Natural Killer Cell |
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| prefixIRI |
Thesaurus:C12536 |
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| Semantic_Type |
Cell |
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| UMLS_CUI |
C0022688 |
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| subClassOf |