loading...| Preferred Name | pravastatin | |
| Synonyms |
[1S-[1alpha(betaS*,deltaS*),2alpha,6alpha,8beta(R*),8aalpha]]-1,2,6,7,8,8a-Hexahydro-beta,!d,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic Acid |
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| Definitions |
A synthetic lipid-lowering agent. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. Pravastatin lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. [url:http://purl.obolibrary.org/obo/NCIT_C62070] |
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| ID |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02126 |
|
| definition |
A synthetic lipid-lowering agent. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. Pravastatin lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. [url:http://purl.obolibrary.org/obo/NCIT_C62070] |
|
| label |
pravastatin |
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| MIO_ID |
MIO:02126 |
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| prefLabel |
pravastatin |
|
| reference |
CHEBI:63618 UMLS:C0085542 NCIT:C62070 |
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| synonyms |
[1S-[1alpha(betaS*,deltaS*),2alpha,6alpha,8beta(R*),8aalpha]]-1,2,6,7,8,8a-Hexahydro-beta,!d,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic Acid |
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| subClassOf |
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:01067 |