loading...| Preferred Name |
plasma cell |
|
| Synonyms |
|
|
| ID |
http://purl.obolibrary.org/obo/LMHA_00574 |
|
| definition |
An epithelial cell that lines the peripheral gas exchange region (epithelial lining of the alveolar duct and alveoli) of the lungs. Includes both alveolar type I and type II pneumocytes. A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin. Plasma cells develop in the spleen and migrate to the bone marrow. Plasma cells are also reportedly CD5-negative, CD10-negative, CD19-positive, CD20-negative, CD21-negative, CD22-negative, CD23-negative, CD24-negative, CD25-negative, CD27-positive, CD34-negative, CD38-positive, CD40-positive, CD43-positive, CD45-positive, CD48-positive, CD53-low, CD80-negative, CD81-positive, CD86-positive, CD95-positive, CD196-negative, CD229-positive, CD270-positive, CD352-positive, CD361-positive, and IgD-negative. Transcription factors: BLIMP1-positive, IRF4-positive, PAX5-negative, SpiB-negative, Ets1-negative, and XBP1-positive. |
|
| has_domain | ||
| hasDbXref |
FMA:70574 BTO:0000392 CL:0000786 LMMA:00677 |
|
| HTC_Code |
BCL |
|
| id |
LMHA:00574 |
|
| isDefinedBy |
CL:0000786 |
|
| label |
plasma cell |
|
| notation |
LMHA:00574 |
|
| part_of | ||
| prefLabel |
plasma cell |
|
| synonym |
mature B lymphocyte |
|
| treeView | ||
| subClassOf |