loading...| Preferred Name | plasma cell | |
| Synonyms |
effector B-cell effector B cell plasma B cell plasma B-cell plasmacyte plasmocyte |
|
| Definitions |
A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin. Plasma cells develop in the spleen and migrate to the bone marrow. Plasma cells are also reportedly CD5-negative, CD10-negative, CD19-positive, CD20-negative, CD21-negative, CD22-negative, CD23-negative, CD24-negative, CD25-negative, CD27-positive, CD34-negative, CD38-positive, CD40-positive, CD43-positive, CD45-positive, CD48-positive, CD53-low, CD80-negative, CD81-positive, CD86-positive, CD95-positive, CD196-negative, CD229-positive, CD270-positive, CD352-positive, CD361-positive, and IgD-negative. Transcription factors: BLIMP1-positive, IRF4-positive, PAX5-negative, SpiB-negative, Ets1-negative, and XBP1-positive. |
|
| ID |
http://purl.obolibrary.org/obo/CL_0000786 |
|
| comment |
Plasma cells develop in the spleen and migrate to the bone marrow. Plasma cells are also reportedly CD5-negative, CD10-negative, CD19-positive, CD20-negative, CD21-negative, CD22-negative, CD23-negative, CD24-negative, CD25-negative, CD27-positive, CD34-negative, CD38-positive, CD40-positive, CD43-positive, CD45-positive, CD48-positive, CD53-low, CD80-negative, CD81-positive, CD86-positive, CD95-positive, CD196-negative, CD229-positive, CD270-positive, CD352-positive, CD361-positive, and IgD-negative. Transcription factors: BLIMP1-positive, IRF4-positive, PAX5-negative, SpiB-negative, Ets1-negative, and XBP1-positive. |
|
| cell has gene marker |
http://purl.obolibrary.org/obo/OGG_3000051237 http://purl.obolibrary.org/obo/OGG_3000000952 http://purl.obolibrary.org/obo/OGG_3000003514 |
|
| database_cross_reference |
MESH:D010950 BTO:0000392 FMA:70574 |
|
| develops_from | ||
| has exact synonym |
plasma B cell plasma B-cell plasmacyte plasmocyte |
|
| has part |
http://purl.obolibrary.org/obo/CL_0017508 |
|
| has plasma membrane part | ||
| has related synonym |
effector B-cell effector B cell |
|
| has_obo_namespace |
cell |
|
| imported from | ||
| in_subset |
http://purl.oboInOwllibrary.org/oboInOwl/uberon/core#human_reference_atlas http://purl.oboInOwllibrary.org/oboInOwl/cl#cellxgene_subset http://purl.oboInOwllibrary.org/oboInOwl/cl#blood_and_immune_upper_slim |
|
| label |
plasma cell |
|
| lacks_plasma_membrane_part |
http://purl.obolibrary.org/obo/PR_000001289 |
|
| overlaps |
http://purl.obolibrary.org/obo/CL_0017508 |
|
| prefixIRI |
CL:0000786 |
|
| prefLabel |
plasma cell |
|
| present_in_taxon | ||
| textual definition |
A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin. |
|
| treeView | ||
| subClassOf |