loading...| Preferred Name | mesenchymal stem cell | |
| Synonyms |
marrow stromal cells colony-forming unit-fibroblast bone marrow stromal cells mesenchymal precursor cell mesenchymal stromal cells mesenchymal stromal cell CFU-F BMSC mesenchymal stem cell MSC stem cells, mesenchymal mesenchymal progenitor cells |
|
| Definitions |
A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs. Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2. |
|
| ID |
http://purl.obolibrary.org/obo/CL_0000134 |
|
| comment |
Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2. |
|
| altLabel |
marrow stromal cells colony-forming unit-fibroblast bone marrow stromal cells mesenchymal precursor cell mesenchymal stromal cells mesenchymal stromal cell CFU-F BMSC mesenchymal stem cell MSC stem cells, mesenchymal mesenchymal progenitor cells |
|
| definition |
A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs. |
|
| has narrow synonym |
marrow stromal cells colony-forming unit-fibroblast bone marrow stromal cells |
|
| has related synonym |
mesenchymal precursor cell mesenchymal stromal cells mesenchymal stromal cell CFU-F BMSC mesenchymal stem cell MSC stem cells, mesenchymal mesenchymal progenitor cells |
|
| in_subset | ||
| label |
mesenchymal stem cell |
|
| prefixIRI |
CL:0000134 |
|
| prefLabel |
mesenchymal stem cell |
|
| see also | ||
| xRef |
FMA:70546 BTO:0002625 ZFA:0009081 BTO:0003298 |
|
| subClassOf |