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Human Phenotype Ontology
| Preferred Name | Endometriosis | |
| Synonyms |
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| Definitions |
The growth of endometrial tissue outside the uterus. The main manifestations of endometriosis are chronic upper abdominal pain and infertility. Endometriosis occurs primarily on the pelvic peritoneum, ovaries, and rectovaginal septum, and in rare cases on the diaphragm, pleura, and pericardium. Endometriosis affects 6 to 10% of women of reproductive age, 50 to 60% of women and teenage girls with pelvic pain, and up to 50% of women with infertility. Peritoneal disease, which is dependent on estrogen for growth, derives from retrograde menstruation of steroid hormone sensitive endometrial cells and tissues, which implant on peritoneal surfaces and elicit an inflammatory response. This response is accompanied by angiogenesis, adhesions, fibrosis, scarring, neuronal infiltration, and anatomical distortion resulting in pain and infertility. |
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| ID |
http://purl.obolibrary.org/obo/HP_0030127 |
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| comment |
The main manifestations of endometriosis are chronic upper abdominal pain and infertility. Endometriosis occurs primarily on the pelvic peritoneum, ovaries, and rectovaginal septum, and in rare cases on the diaphragm, pleura, and pericardium. Endometriosis affects 6 to 10% of women of reproductive age, 50 to 60% of women and teenage girls with pelvic pain, and up to 50% of women with infertility. Peritoneal disease, which is dependent on estrogen for growth, derives from retrograde menstruation of steroid hormone sensitive endometrial cells and tissues, which implant on peritoneal surfaces and elicit an inflammatory response. This response is accompanied by angiogenesis, adhesions, fibrosis, scarring, neuronal infiltration, and anatomical distortion resulting in pain and infertility.
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| database_cross_reference |
SNOMEDCT_US:129103003 SNOMEDCT_US:396224008 UMLS:C0014175
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| definition |
The growth of endometrial tissue outside the uterus.
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| has_alternative_id |
HP:0030013
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| has_obo_namespace |
human_phenotype
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| id |
HP:0030127
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| label |
Endometriosis
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| notation |
HP:0030127
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| prefLabel |
Endometriosis
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| subClassOf |
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