loading...| Preferred Name | endocrine system | |
| Synonyms |
endocrine glandular system systema endocrinum endocrine system |
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| Definitions |
Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity. |
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| ID |
http://purl.obolibrary.org/obo/UBERON_0000949 |
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| composed_primarily_of | ||
| database cross reference |
http://linkedlifedata.com/resource/umls/id/C0014136 http://en.wikipedia.org/wiki/Endocrine_system http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C12705 http://www.snomedbrowser.com/Codes/Details/278876000 MESH:D004703 FMA:9668 EHDAA2:0002224 MA:0000012 ZFA:0001158 GAID:439 AAO:0010279 EMAPA:35306 TAO:0001158 XAO:0000158 FBbt:00005068 UMLS:C0014136 CALOHA:TS-1301 VHOG:0000098 EV:0100128 EFO:0002969 |
|
| definition |
Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity. |
|
| external definition |
Anatomical system containing glands which regulates bodily functions though the secretion of hormones.[AAO] |
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| has part | ||
| has_exact_synonym |
endocrine glandular system systema endocrinum endocrine system |
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| homology notes |
Multicellular organisms have complex endocrine systems, allowing responses to environmental stimuli, regulation of development, reproduction, and homeostasis. Nuclear receptors (NRs), a metazoan-specific family of ligand-activated transcription factors, play central roles in endocrine responses, as intermediates between signaling molecules and target genes. The NR family includes ligand-bound and orphan receptors, that is, receptors with no known ligand or for which there is no ligand Pocket. Understanding NR evolution has been further improved by comparison of several completed genomes, particularly those of deuterostomes and ecdysozoans. In contrast, evolution of NR ligands is still much debated. One hypothesis proposes that several independent gains and losses of ligand-binding ability in NRs occurred in protostomes and deuterostomes. A second hypothesis, pertaining to the NR3 subfamily (vertebrate steroid hormone receptors and estrogen related receptor), proposes that before the divergence of protostomes and deuterostomes, there was an ancestral steroid receptor (AncSR) that was ligand-activated and that orphan receptors secondarily lost the ability to bind a ligand. (...) Our analysis reveals that steroidogenesis has been independently elaborated in the 3 main bilaterian lineages (...).[well established][VHOG] |
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| imported from | ||
| label |
endocrine system |
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| prefixIRI |
UBERON:0000949 |
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| prefLabel |
endocrine system |
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| subClassOf |