Authored: Akkerman, JW, 2009-06-03 Edited: Jupe, S, 2010-09-01 Reviewed: Heemskerk, JW, 2010-09-01 Rap1 (Ras-proximate-1) is a small G protein in the Ras superfamily. Like all G proteins, Rap1 is activated when bound GDP is exchanged for GTP. Rap1 is targeted to lipid membranes by the covalent attachment of lipid moieties to its carboxyl terminus. Movement of Rap1 from endosomal membranes to the plasma membrane upon activation has been reported in several cell types including Jurkat T cells and megakaryocytes. On activation, Rap1 undergoes conformational changes that facilitate recruitment of a variety of effectors, triggering it's participation in integrin signaling, ERK activation, and others.

http://purl.obolibrary.org/obo/HINO_0022392

Authored: Akkerman, JW, 2009-06-03

Edited: Jupe, S, 2010-09-01

Reviewed: Heemskerk, JW, 2010-09-01

Rap1 (Ras-proximate-1) is a small G protein in the Ras superfamily. Like all G proteins, Rap1 is activated when bound GDP is exchanged for GTP. Rap1 is targeted to lipid membranes by the covalent attachment of lipid moieties to its carboxyl terminus. Movement of Rap1 from endosomal membranes to the plasma membrane upon activation has been reported in several cell types including Jurkat T cells and megakaryocytes. On activation, Rap1 undergoes conformational changes that facilitate recruitment of a variety of effectors, triggering it's participation in integrin signaling, ERK activation, and others.

Pubmed16076873

Reactome, http://www.reactome.org

Rap1 signalling

http://purl.obolibrary.org/obo/NCBITaxon_9606

HINO:0022392

Rap1 signalling

ReactomeREACT_23898

Reactome Database ID Release 43392517

http://purl.obolibrary.org/obo/INO_0000021

http://purl.obolibrary.org/obo/HINO_0018117

http://purl.obolibrary.org/obo/HINO_0018116

http://purl.obolibrary.org/obo/HINO_0018115

http://purl.obolibrary.org/obo/HINO_0018091

http://purl.obolibrary.org/obo/HINO_0018090

http://purl.obolibrary.org/obo/HINO_0014349

http://purl.obolibrary.org/obo/HINO_0014348