loading...| Preferred Name | Activation of EPACs by cAMP | |
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has a Stoichiometric coefficient of 2 Authored: Akkerman, JW, 2009-06-03 EPACs (exchange proteins directly activated by cAMP) are Rap1 GEFs that are activated by direct binding of cAMP (cyclic adenosine monophosphate). cAMP-GEFI (EPAC1) is widely expressed, while cAMP-GEFII (EPAC2) is enriched in brain and adrenal tissue. Both are selective for Rap1. A role of EPACs has been proposed for Rap1-dependent cell adhesion to laminin in both epithelial and red blood cells, and in the regulation of vascular endothelial barrier function. Edited: Jupe, S, 2010-09-01 Reviewed: Heemskerk, JW, 2010-09-01 |
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http://purl.obolibrary.org/obo/HINO_0018117 |
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has a Stoichiometric coefficient of 2 Authored: Akkerman, JW, 2009-06-03 EPACs (exchange proteins directly activated by cAMP) are Rap1 GEFs that are activated by direct binding of cAMP (cyclic adenosine monophosphate). cAMP-GEFI (EPAC1) is widely expressed, while cAMP-GEFII (EPAC2) is enriched in brain and adrenal tissue. Both are selective for Rap1. A role of EPACs has been proposed for Rap1-dependent cell adhesion to laminin in both epithelial and red blood cells, and in the regulation of vascular endothelial barrier function. Edited: Jupe, S, 2010-09-01 Reviewed: Heemskerk, JW, 2010-09-01 |
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| definition source |
Pubmed16076873 Reactome, http://www.reactome.org Pubmed9789079 |
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Activation of EPACs by cAMP |
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| prefixIRI |
HINO:0018117 |
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Activation of EPACs by cAMP |
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ReactomeREACT_23933 Reactome Database ID Release 43392834 |
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