loading...| Preferred Name | Activation of Rap1 by cytosolic GEFs | |
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Authored: Garapati, P V, 2008-06-16 17:13:06 Signals from agonist receptors (such as GPVI) trigger the production of PIP3, DAG, cAMP and elevated Ca++ levels. This leads to the activation and translocation of active Rap1-GTP to the plasma membrane. Rap-GEFs stimulate the replacement of GDP for GTP, activating Rap1. Several Rap1 GEFs have been identified enabling Rap1 to respond to diverse stimuli. CalDAG-GEFs activate Rap1 in response to calcium and DAG, downstream of Phospholipase C. EPAC (exchange proteins directly activated by cAMP) GEFs are activated by binding cAMP. Edited: Garapati, P V, 2008-06-16 17:13:06 Reviewed: Shattil, SJ, 2008-09-16 06:21:39 |
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http://purl.obolibrary.org/obo/HINO_0014349 |
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Authored: Garapati, P V, 2008-06-16 17:13:06 Signals from agonist receptors (such as GPVI) trigger the production of PIP3, DAG, cAMP and elevated Ca++ levels. This leads to the activation and translocation of active Rap1-GTP to the plasma membrane. Rap-GEFs stimulate the replacement of GDP for GTP, activating Rap1. Several Rap1 GEFs have been identified enabling Rap1 to respond to diverse stimuli. CalDAG-GEFs activate Rap1 in response to calcium and DAG, downstream of Phospholipase C. EPAC (exchange proteins directly activated by cAMP) GEFs are activated by binding cAMP. Edited: Garapati, P V, 2008-06-16 17:13:06 Reviewed: Shattil, SJ, 2008-09-16 06:21:39 |
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| definition source |
Pubmed15469846 Pubmed16076873 Reactome, http://www.reactome.org Pubmed16757337 Pubmed15334074 Pubmed12585966 |
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Activation of Rap1 by cytosolic GEFs |
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HINO:0014349 |
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Activation of Rap1 by cytosolic GEFs |
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Reactome Database ID Release 43354173 ReactomeREACT_15507 |
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