loading...| Preferred Name | Activation of NF-kappaB in B Cells | |
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Edited: May, B, 2011-01-03 Authored: May, B, 2011-01-03 DAG and calcium activate protein kinase C beta (PKC-beta, Kochs et al. 1991) which phosphorylates CARMA1 and other proteins (Sommer et al. 2005). Phosphorylated CARMA1 recruits BCL10 and MALT1 to form the CBM complex (Sommer et al. 2005, Tanner et al. 2007) which, in turn, recruits the kinase TAK1 and the IKK complex (Sommer et al. 2005, Shinohara et al. 2005 using chicken cells). TAK1 phosphorylates the IKK-beta subunit, activating it (Wang et al. 2001). The IKK complex then phosphorylates IkB complexed with NF-kappaB dimers in the cytosol (Zandi et al. 1998, Burke et al. 1999, Heilker et al. 1999), resulting in the degradation of IkB (Miyamoto et al. 1994, Traenckner et al. 1994, Alkalay et al. 1995, DiDonato et al. 1995, Li et al. 1995, Lin et al. 1995, Scherer et al. 1995, Chen et al. 1995). NF-kappaB dimers are thereby released and are translocated to the nucleus where they activate transcription (Baeuerle and Baltimore 1988, Blank et al. 1991, Ghosh et al. 2008, Fagerlund et al. 2008). Reviewed: Wienands, J, 2012-02-11 |
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http://purl.obolibrary.org/obo/HINO_0022377 |
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Edited: May, B, 2011-01-03 Authored: May, B, 2011-01-03 DAG and calcium activate protein kinase C beta (PKC-beta, Kochs et al. 1991) which phosphorylates CARMA1 and other proteins (Sommer et al. 2005). Phosphorylated CARMA1 recruits BCL10 and MALT1 to form the CBM complex (Sommer et al. 2005, Tanner et al. 2007) which, in turn, recruits the kinase TAK1 and the IKK complex (Sommer et al. 2005, Shinohara et al. 2005 using chicken cells). TAK1 phosphorylates the IKK-beta subunit, activating it (Wang et al. 2001). The IKK complex then phosphorylates IkB complexed with NF-kappaB dimers in the cytosol (Zandi et al. 1998, Burke et al. 1999, Heilker et al. 1999), resulting in the degradation of IkB (Miyamoto et al. 1994, Traenckner et al. 1994, Alkalay et al. 1995, DiDonato et al. 1995, Li et al. 1995, Lin et al. 1995, Scherer et al. 1995, Chen et al. 1995). NF-kappaB dimers are thereby released and are translocated to the nucleus where they activate transcription (Baeuerle and Baltimore 1988, Blank et al. 1991, Ghosh et al. 2008, Fagerlund et al. 2008). Reviewed: Wienands, J, 2012-02-11 |
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| definition source |
Pubmed1756723 Pubmed7479848 Pubmed7831327 Pubmed11460167 Pubmed9721103 Pubmed17428801 Pubmed18462924 Pubmed9914500 Pubmed16301747 Pubmed3129195 Reactome, http://www.reactome.org Pubmed7957109 Pubmed7862124 Pubmed7809113 Pubmed10593898 Pubmed7479976 Pubmed7628694 Pubmed8387275 Pubmed16356855 Pubmed19066035 Pubmed7575604 |
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Activation of NF-kappaB in B Cells |
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| prefixIRI |
HINO:0022377 |
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Activation of NF-kappaB in B Cells |
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ReactomeREACT_118656 Reactome Database ID Release 431169091 |
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http://purl.obolibrary.org/obo/HINO_0017732 http://purl.obolibrary.org/obo/HINO_0017734 http://purl.obolibrary.org/obo/HINO_0017735 http://purl.obolibrary.org/obo/HINO_0017769 http://purl.obolibrary.org/obo/HINO_0017764 http://purl.obolibrary.org/obo/HINO_0017765 http://purl.obolibrary.org/obo/HINO_0017766 http://purl.obolibrary.org/obo/HINO_0017767 |