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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0017734
http://purl.obolibrary.org/obo/HINO_0017734
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| Preferred Name | Phosphorylation of CARMA1 in B Cells |
| Definitions |
Authored: May, B, 2010-12-18
Edited: May, B, 2010-12-18
CARMA1 is phosphorylated at serines 559, 644, and 652 by Protein Kinase C beta (PKC-beta) (Sommer et al. 2005). CARMA1 is constitutively oligomerized (Tanner et al. 2007) and most CARMA1 in unstimulated cells is cytosolic (Sommer et al. 2005, Tanner et al. 2007), though a portion is constitutively associated with the plasma membrane (Gaide et al. 2002, Sommer et al. 2005). After phosphorylation, CARMA1 is associated with lipid rafts in the plasma membrane (Sommer et al. 2005). Note that some publications refer to CARMA1 with a different N-terminal methionine that is 7 amino acids shorter. In this case the phosphorylated serines are 552, 537, and 645.
Reviewed: Wienands, J, 2012-02-11
has a Stoichiometric coefficient of 6
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Phosphorylation of CARMA1 in B Cells
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| comment |
Authored: May, B, 2010-12-18
Edited: May, B, 2010-12-18
CARMA1 is phosphorylated at serines 559, 644, and 652 by Protein Kinase C beta (PKC-beta) (Sommer et al. 2005). CARMA1 is constitutively oligomerized (Tanner et al. 2007) and most CARMA1 in unstimulated cells is cytosolic (Sommer et al. 2005, Tanner et al. 2007), though a portion is constitutively associated with the plasma membrane (Gaide et al. 2002, Sommer et al. 2005). After phosphorylation, CARMA1 is associated with lipid rafts in the plasma membrane (Sommer et al. 2005). Note that some publications refer to CARMA1 with a different N-terminal methionine that is 7 amino acids shorter. In this case the phosphorylated serines are 552, 537, and 645.
Reviewed: Wienands, J, 2012-02-11
has a Stoichiometric coefficient of 6
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| prefLabel |
Phosphorylation of CARMA1 in B Cells
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| definition source |
Reactome, http://www.reactome.org
Pubmed16356855
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| prefixIRI |
HINO:0017734
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| seeAlso |
ReactomeREACT_118598
Reactome Database ID Release 431168635
EC Number: 2.7.11
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| has output |
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