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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0017732
http://purl.obolibrary.org/obo/HINO_0017732
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| Preferred Name | TAK1 Associated with the CBM Complex Phosphorylates IKKbeta |
| Definitions |
Authored: May, B, 2010-12-18
Edited: May, B, 2010-12-18
TAK1 phosphorylates IKK-beta (Wang et al. 2001). As inferred from chicken B cells, the reaction in human B cells may occur when TAK1 and the IKK complex are associated with the CARMA1:BCL10:MALT1 (CBM) complex. During T cell activation TAK1 forms a complex with TAB1 and TAB2, which binds K-63 conjugated polyubiquitin attached to TRAF6 associated with the CBM complex (Sun et al. 2004, reviewed in Shinohara et al. 2009). TRAF6 also polyubiquitinates IKK-gamma in T cells (Zhou et al. 2004). B cells contain functional TRAF6 and TRAF2 (Zhang et al. 2010) so the same mechanism may occur during activation of B cells.
Reviewed: Wienands, J, 2012-02-11
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
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TAK1 Associated with the CBM Complex Phosphorylates IKKbeta
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| comment |
Authored: May, B, 2010-12-18
Edited: May, B, 2010-12-18
TAK1 phosphorylates IKK-beta (Wang et al. 2001). As inferred from chicken B cells, the reaction in human B cells may occur when TAK1 and the IKK complex are associated with the CARMA1:BCL10:MALT1 (CBM) complex. During T cell activation TAK1 forms a complex with TAB1 and TAB2, which binds K-63 conjugated polyubiquitin attached to TRAF6 associated with the CBM complex (Sun et al. 2004, reviewed in Shinohara et al. 2009). TRAF6 also polyubiquitinates IKK-gamma in T cells (Zhou et al. 2004). B cells contain functional TRAF6 and TRAF2 (Zhang et al. 2010) so the same mechanism may occur during activation of B cells.
Reviewed: Wienands, J, 2012-02-11
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| prefLabel |
TAK1 Associated with the CBM Complex Phosphorylates IKKbeta
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| definition source |
Pubmed11460167
Pubmed20449947
Pubmed16301747
Pubmed14695475
Reactome, http://www.reactome.org
Pubmed19909372
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| prefixIRI |
HINO:0017732
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| seeAlso |
Reactome Database ID Release 431168641
ReactomeREACT_118689
EC Number: 2.7.11
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