loading...| Preferred Name | Toll Receptor Cascades | |
| Synonyms |
|
|
| Definitions |
In human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) domain in their cytoplasmic region and an Ig-like domain in the extracellular region, where each is enriched with a varying number of leucine-rich repeats (LRRs). Each TLR can recognize specific microbial pathogen components. The binding pathogens component of the TLRs initializes signaling pathways that lead to induction of Interferon alpha/beta. There are three main signaling pathways: the first is a MyD88-dependent pathway that is common to all TLRs, except TLR3; the second is a TRAM-dependent pathway that is peculiar to TLR3 and TLR4 and is mediated by TRIF and RIP1; and the third is a TRAF6-mediated pathway peculiar to TLR3 (Takeda & Akira 2004; Akira 2003; Takeda & Akira 2005; Kawai 2005; Heine & Ulmer 2005). Authored: de Bono, B, Gillespie, ME, Luo, F, Gay, NJ, 0000-00-00 00:00:00 Reviewed: D'Eustachio, P, Gale M, Jr, Gay, NJ, 2006-10-31 16:43:59 |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0022353 |
|
| comment |
In human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) domain in their cytoplasmic region and an Ig-like domain in the extracellular region, where each is enriched with a varying number of leucine-rich repeats (LRRs). Each TLR can recognize specific microbial pathogen components. The binding pathogens component of the TLRs initializes signaling pathways that lead to induction of Interferon alpha/beta. There are three main signaling pathways: the first is a MyD88-dependent pathway that is common to all TLRs, except TLR3; the second is a TRAM-dependent pathway that is peculiar to TLR3 and TLR4 and is mediated by TRIF and RIP1; and the third is a TRAF6-mediated pathway peculiar to TLR3 (Takeda & Akira 2004; Akira 2003; Takeda & Akira 2005; Kawai 2005; Heine & Ulmer 2005). Authored: de Bono, B, Gillespie, ME, Luo, F, Gay, NJ, 0000-00-00 00:00:00 Reviewed: D'Eustachio, P, Gale M, Jr, Gay, NJ, 2006-10-31 16:43:59 |
|
| definition source |
Pubmed15976490 Pubmed14751757 Reactome, http://www.reactome.org Pubmed12893815 Pubmed15585605 Pubmed15950447 |
|
| label |
Toll Receptor Cascades |
|
| located_in | ||
| prefixIRI |
HINO:0022353 |
|
| prefLabel |
Toll Receptor Cascades |
|
| seeAlso |
ReactomeREACT_6966 Reactome Database ID Release 43168898 |
|
| subClassOf | ||
| has_part |
http://purl.obolibrary.org/obo/HINO_0022360 http://purl.obolibrary.org/obo/HINO_0022348 http://purl.obolibrary.org/obo/HINO_0021954 http://purl.obolibrary.org/obo/HINO_0021953 http://purl.obolibrary.org/obo/HINO_0022358 http://purl.obolibrary.org/obo/HINO_0022314 |