loading...| Preferred Name | Toll Like Receptor 3 (TLR3) Cascade | |
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| Definitions |
Edited: Shamovsky, V, 2011-08-12 Authored: Luo, F, 2005-11-10 11:23:18 Reviewed: Gay, NJ, 2006-04-24 16:48:17 Toll-like receptor 3 (TLR3) as was shown for mammals is expressed on myeloid dendritic cells, respiratory epithelium, macrophages, and appears to play a central role in mediating the antiviral and inflammatory responses of the innate immunity in combating viral infections.<p>Mammalian TLR3 recognizes dsRNA, and that triggers the receptor to induce the activation of NF-kappaB and the production of type I interferons (IFNs). dsRNA-stimulated phosphorylation of two specific TLR3 tyrosine residues (Tyr759 and Tyr858) is essential for initiating TLR3 signaling pathways. |
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http://purl.obolibrary.org/obo/HINO_0022348 |
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Edited: Shamovsky, V, 2011-08-12 Authored: Luo, F, 2005-11-10 11:23:18 Reviewed: Gay, NJ, 2006-04-24 16:48:17 Toll-like receptor 3 (TLR3) as was shown for mammals is expressed on myeloid dendritic cells, respiratory epithelium, macrophages, and appears to play a central role in mediating the antiviral and inflammatory responses of the innate immunity in combating viral infections. Mammalian TLR3 recognizes dsRNA, and that triggers the receptor to induce the activation of NF-kappaB and the production of type I interferons (IFNs). dsRNA-stimulated phosphorylation of two specific TLR3 tyrosine residues (Tyr759 and Tyr858) is essential for initiating TLR3 signaling pathways. |
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| definition source |
Pubmed15031527 Reactome, http://www.reactome.org Pubmed19627256 Pubmed15733829 Pubmed18202435 |
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Toll Like Receptor 3 (TLR3) Cascade |
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HINO:0022348 |
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Toll Like Receptor 3 (TLR3) Cascade |
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| seeAlso |
Reactome Database ID Release 43168164 ReactomeREACT_6783 GENE ONTOLOGYGO:0034138 |
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