loading...| Preferred Name |
Negative regulation of FGFR signaling |
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| Synonyms |
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| Definitions |
Reviewed: Gotoh, N, 2011-08-26 Authored: Rothfels, K, 2011-08-15 Once activated, the FGFR signaling pathway is regulated by numerous negative feedback mechanisms. These include downregulation of receptors through CBL-mediated ubiquitination and endocytosis, ERK-mediated inhibition of FRS2-tyrosine phosphorylation and the attenuation of ERK signaling through the action of dual-specificity phosphatases, IL17RD/SEF, Sprouty and Spred proteins. A number of these inhibitors are themselves transcriptional targets of the activated FGFR pathway. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0016293 |
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| comment |
Reviewed: Gotoh, N, 2011-08-26 Authored: Rothfels, K, 2011-08-15 Once activated, the FGFR signaling pathway is regulated by numerous negative feedback mechanisms. These include downregulation of receptors through CBL-mediated ubiquitination and endocytosis, ERK-mediated inhibition of FRS2-tyrosine phosphorylation and the attenuation of ERK signaling through the action of dual-specificity phosphatases, IL17RD/SEF, Sprouty and Spred proteins. A number of these inhibitors are themselves transcriptional targets of the activated FGFR pathway. |
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| definition source |
Pubmed12815057 Pubmed20940169 Reactome, http://www.reactome.org Pubmed18452557 Pubmed11997436 |
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| label |
Negative regulation of FGFR signaling |
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| located_in | ||
| prefixIRI |
HINO:0016293 |
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| prefLabel |
Negative regulation of FGFR signaling |
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| seeAlso |
ReactomeREACT_111184 Reactome Database ID Release 431270470 |
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| has_part |
http://purl.obolibrary.org/obo/HINO_0016297 http://purl.obolibrary.org/obo/HINO_0009012 |