loading...| Preferred Name | p-CBL:GRB2 binds p-FRS2alpha:activated FGFR | |
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| Definitions |
Reviewed: Gotoh, N, 2011-08-26 The ubiquitin ligase CBL exists in a complex with GRB2 and is recruited to tyrosine-phosphorylated FRS2 after FGF stimulation. In addition to promoting the ubiquitination, endocytosis, and degradation of the activated receptor complex, recruitment of the p-CBL:GRB2 complex seems to attenuate FGFR signaling by competing with GRB2:SOS1 for binding to the direct GRB2-binding sites on p-FRS2. Authored: Rothfels, K, 2011-08-15 |
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http://purl.obolibrary.org/obo/HINO_0009013 |
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Reviewed: Gotoh, N, 2011-08-26 The ubiquitin ligase CBL exists in a complex with GRB2 and is recruited to tyrosine-phosphorylated FRS2 after FGF stimulation. In addition to promoting the ubiquitination, endocytosis, and degradation of the activated receptor complex, recruitment of the p-CBL:GRB2 complex seems to attenuate FGFR signaling by competing with GRB2:SOS1 for binding to the direct GRB2-binding sites on p-FRS2. Authored: Rothfels, K, 2011-08-15 |
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| definition source |
Reactome, http://www.reactome.org Pubmed11997436 |
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p-CBL:GRB2 binds p-FRS2alpha:activated FGFR |
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HINO:0009013 |
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p-CBL:GRB2 binds p-FRS2alpha:activated FGFR |
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| seeAlso |
Reactome Database ID Release 431270439 ReactomeREACT_111145 |
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