loading...| Preferred Name |
Activated ERK1/2 threonine-phosphorylate FRS2alpha. |
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| Definitions |
Reviewed: Gotoh, N, 2011-08-26 Authored: Rothfels, K, 2011-08-15 has a Stoichiometric coefficient of 8 FRS2alpha has 8 canonical MAPK phosphorylation sites which are phosphorylated by activated ERK1/2 after FGF stimulation. Phosphorylation of these 8 threonine residues counteracts the activating effect of tyrosine phosphorylation of FRS2alpha, although the exact mechanism for this negative regulation is not known. Expression of a version of FRS2alpha in which the 8 threonine residues are mutated to valine results in enhanced tyrosine phosphorylation of FRS2alpha, enhanced GRB2-SOS1 recruitment and a more sustained MAPK response. The 8 threonine residues are not conserved in FRS2beta; as a result, signaling through FRS2beta complexes do not appear to be subject to this downregulation. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0009012 |
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| comment |
Reviewed: Gotoh, N, 2011-08-26 Authored: Rothfels, K, 2011-08-15 has a Stoichiometric coefficient of 8 FRS2alpha has 8 canonical MAPK phosphorylation sites which are phosphorylated by activated ERK1/2 after FGF stimulation. Phosphorylation of these 8 threonine residues counteracts the activating effect of tyrosine phosphorylation of FRS2alpha, although the exact mechanism for this negative regulation is not known. Expression of a version of FRS2alpha in which the 8 threonine residues are mutated to valine results in enhanced tyrosine phosphorylation of FRS2alpha, enhanced GRB2-SOS1 recruitment and a more sustained MAPK response. The 8 threonine residues are not conserved in FRS2beta; as a result, signaling through FRS2beta complexes do not appear to be subject to this downregulation. |
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| definition source |
Pubmed12974390 Pubmed19652666 Reactome, http://www.reactome.org Pubmed18452557 Pubmed12419216 |
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| label |
Activated ERK1/2 threonine-phosphorylate FRS2alpha. |
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| prefixIRI |
HINO:0009012 |
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| prefLabel |
Activated ERK1/2 threonine-phosphorylate FRS2alpha. |
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| seeAlso |
ReactomeREACT_111161 Reactome Database ID Release 431270466 EC Number: 2.7.11.24 |
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