loading...| Preferred Name |
Signaling by FGFR |
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| Definitions |
Reviewed: Gotoh, N, 2011-08-26 Authored: de Bono, B, 2007-01-10 10:27:18 Edited: de Bono, B, D'Eustachio, P, 2007-02-10 20:21:22 The 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosine kinases (RTKs) designated FGFR1, FGFR2, FGFR3 and FGFR4. These receptors are key regulators of several developmental processes in which cell fate and differentiation to various tissue lineages are determined. Unlike other growth factors, FGFs act in concert with heparin or heparan sulfate proteoglycan (HSPG) to activate FGFRs and to induce the pleiotropic responses that lead to the variety of cellular responses induced by this large family of growth factors. An alternative, FGF-independent, source of FGFR activation originates from the interaction with cell adhesion molecules, typically in the context of interactions on neural cell membranes and is crucial for neuronal survival and development.<br><br>Upon ligand binding, receptor dimers are formed and their intrinsic tyrosine kinase is activated causing phosphorylation of multiple tyrosine residues on the receptors. These then serve as docking sites for the recruitment of SH2 (src homology-2) or PTB (phosphotyrosine binding) domains of adaptors, docking proteins or signaling enzymes. Signaling complexes are assembled and recruited to the active receptors resulting in a cascade of phosphorylation events.<br><br>This leads to stimulation of intracellular signaling pathways that control cell proliferation, cell differentiation, cell migration, cell survival and cell shape, depending on the cell type or stage of maturation.<br> Reviewed: Mohammadi, M, 2007-02-06 21:44:35 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0016061 |
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| comment |
Reviewed: Gotoh, N, 2011-08-26 Authored: de Bono, B, 2007-01-10 10:27:18 Edited: de Bono, B, D'Eustachio, P, 2007-02-10 20:21:22 The 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosine kinases (RTKs) designated FGFR1, FGFR2, FGFR3 and FGFR4. These receptors are key regulators of several developmental processes in which cell fate and differentiation to various tissue lineages are determined. Unlike other growth factors, FGFs act in concert with heparin or heparan sulfate proteoglycan (HSPG) to activate FGFRs and to induce the pleiotropic responses that lead to the variety of cellular responses induced by this large family of growth factors. An alternative, FGF-independent, source of FGFR activation originates from the interaction with cell adhesion molecules, typically in the context of interactions on neural cell membranes and is crucial for neuronal survival and development. Reviewed: Mohammadi, M, 2007-02-06 21:44:35 |
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| definition source |
Pubmed19247306 Pubmed15567848 Pubmed15863038 Pubmed20602996 Pubmed16597617 Pubmed7917292 Reactome, http://www.reactome.org Pubmed12080084 Pubmed15863030 |
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Signaling by FGFR |
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| located_in | ||
| name |
Fibroblast Growth Factor Receptor (FGFR) signaling |
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| prefixIRI |
HINO:0016061 |
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| prefLabel |
Signaling by FGFR |
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| seeAlso |
Reactome Database ID Release 43190236 ReactomeREACT_9470 GENE ONTOLOGYGO:0008543 |
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| has_part |
http://purl.obolibrary.org/obo/HINO_0009060 http://purl.obolibrary.org/obo/HINO_0009061 http://purl.obolibrary.org/obo/HINO_0016039 http://purl.obolibrary.org/obo/HINO_0016060 |