loading...| Preferred Name | Early Phase of HIV Life Cycle | |
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| Definitions |
In the <b>early phase </b> of HIV lifecycle, an active virion binds and enters a target cell mainly by specific interactions of the viral envelope proteins with host cell surface receptors. The virion core is uncoated to expose a viral nucleoprotein complex containing RNA and viral proteins. HIV RNA genome is reverse transcribed by the viral Reverse Transcriptase to form a cDNA copy, that gets inserted into host cell DNA. The viral Integrase enzyme is vital to carry out the integration of the viral cDNA into the host genome. The host DNA repair enzymes probably repair the breaks in DNA at the sites of integration. Authored: Iordanskiy, S, Morrow, MP, Gopinathrao, G, D'Eustachio, P, Bukrinsky, M, 2006-05-16 18:51:52 Reviewed: Aiken, C, Bushman, FD, Hughes, SH, Reeves, J, 2006-10-30 22:07:21 Edited: Gopinathrao, G, 2006-02-17 18:35:46 Edited: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0015732 |
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| comment |
In the early phase of HIV lifecycle, an active virion binds and enters a target cell mainly by specific interactions of the viral envelope proteins with host cell surface receptors. The virion core is uncoated to expose a viral nucleoprotein complex containing RNA and viral proteins. HIV RNA genome is reverse transcribed by the viral Reverse Transcriptase to form a cDNA copy, that gets inserted into host cell DNA. The viral Integrase enzyme is vital to carry out the integration of the viral cDNA into the host genome. The host DNA repair enzymes probably repair the breaks in DNA at the sites of integration. Authored: Iordanskiy, S, Morrow, MP, Gopinathrao, G, D'Eustachio, P, Bukrinsky, M, 2006-05-16 18:51:52 Reviewed: Aiken, C, Bushman, FD, Hughes, SH, Reeves, J, 2006-10-30 22:07:21 Edited: Gopinathrao, G, 2006-02-17 18:35:46 Edited: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22 |
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| definition source |
Reactome, http://www.reactome.org Pubmed12091904 |
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| label |
Early Phase of HIV Life Cycle |
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| located_in | ||
| prefixIRI |
HINO:0015732 |
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| prefLabel |
Early Phase of HIV Life Cycle |
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| seeAlso |
ReactomeREACT_6266 GENE ONTOLOGYGO:0022415 Reactome Database ID Release 43162594 |
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| has_part |
http://purl.obolibrary.org/obo/HINO_0026323 http://purl.obolibrary.org/obo/HINO_0015730 http://purl.obolibrary.org/obo/HINO_0015731 http://purl.obolibrary.org/obo/HINO_0026312 http://purl.obolibrary.org/obo/HINO_0015729 |