loading...| Preferred Name | Uncoating of the HIV Virion | |
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Reviewed: Aiken, C, 2006-10-30 22:04:39 Authored: Iordanskiy, S, Bukrinsky, M, 2006-04-03 16:17:37 HIV-1 uncoating is a poorly understood process. It likely involves a progressive and partial dissembly of matrix and capsid layers. While viral proteins like MA and Nef are thought to be involved, the primary cause seems to be the cytosolic pH and a simple dilution effect. Successful uncoating generates the viral reverse transcription complex, which comprises the diploid viral RNA genome, tRNALys primer, RT, IN, MA, nucleocapsid (NC), viral protein R (Vpr) and various host proteins; the reverse-transcription complex is thus liberated from the plasma membrane. It is believed that the transiting viral nucleoprotein complex associates with the elements of cytoskeleton like actin microfilaments. Edited: Gopinathrao, G, 2006-02-17 18:35:46 |
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http://purl.obolibrary.org/obo/HINO_0015730 |
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Reviewed: Aiken, C, 2006-10-30 22:04:39 Authored: Iordanskiy, S, Bukrinsky, M, 2006-04-03 16:17:37 HIV-1 uncoating is a poorly understood process. It likely involves a progressive and partial dissembly of matrix and capsid layers. While viral proteins like MA and Nef are thought to be involved, the primary cause seems to be the cytosolic pH and a simple dilution effect. Successful uncoating generates the viral reverse transcription complex, which comprises the diploid viral RNA genome, tRNALys primer, RT, IN, MA, nucleocapsid (NC), viral protein R (Vpr) and various host proteins; the reverse-transcription complex is thus liberated from the plasma membrane. It is believed that the transiting viral nucleoprotein complex associates with the elements of cytoskeleton like actin microfilaments. Edited: Gopinathrao, G, 2006-02-17 18:35:46 |
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| definition source |
Pubmed12417576 Reactome, http://www.reactome.org Pubmed12091904 Pubmed15502876 Pubmed15700618 |
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Uncoating of the HIV Virion |
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HINO:0015730 |
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Uncoating of the HIV Virion |
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GENE ONTOLOGYGO:0019061 Reactome Database ID Release 43162585 ReactomeREACT_6965 |
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