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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0026312
http://purl.obolibrary.org/obo/HINO_0026312
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|---|---|
| Preferred Name | Annealing of 3'-end of unwound transfer RNA primer with genomic RNA |
| Definitions |
Reviewed: Hughes, SH, 2006-10-30 22:00:51
Retroviruses use cellular tRNAs as primers for reverse transcription of the viral genomic RNA (Mak and Kleiman 1997). The primer tRNA is selectively packaged during assembly of retrovirus particles. In the case of HIV-1, lysine tRNAs are preferentially incorporated during retroviral packaging, and lysine tRNA 3, the specific isoacceptor form that serves as a primer for reverse transcription, anneals to the PBS (primer binding site) within the U5 region of the viral genomic RNA. This association appears to be mediated by the viral reverse transcriptase (RT) protein, possibly its "thumb" and "connection" domains (Jiang et al. 1993; Mak et al. 1994; Mishima and Steitz 1995).
Edited: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22
Authored: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Annealing of 3'-end of unwound transfer RNA primer with genomic RNA
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| comment |
Reviewed: Hughes, SH, 2006-10-30 22:00:51
Retroviruses use cellular tRNAs as primers for reverse transcription of the viral genomic RNA (Mak and Kleiman 1997). The primer tRNA is selectively packaged during assembly of retrovirus particles. In the case of HIV-1, lysine tRNAs are preferentially incorporated during retroviral packaging, and lysine tRNA 3, the specific isoacceptor form that serves as a primer for reverse transcription, anneals to the PBS (primer binding site) within the U5 region of the viral genomic RNA. This association appears to be mediated by the viral reverse transcriptase (RT) protein, possibly its "thumb" and "connection" domains (Jiang et al. 1993; Mak et al. 1994; Mishima and Steitz 1995).
Edited: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22
Authored: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22
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| prefLabel |
Annealing of 3'-end of unwound transfer RNA primer with genomic RNA
|
| definition source |
Pubmed9343157
Reactome, http://www.reactome.org
Pubmed7511167
Pubmed8497049
Pubmed7540137
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| prefixIRI |
HINO:0026312
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| seeAlso |
GENE ONTOLOGYGO:0006278
Reactome Database ID Release 43164527
ReactomeREACT_9015
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| subClassOf | |
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| has output |
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