Reviewed: Hughes, SH, 2006-10-30 22:00:51 The fate of the discontinuous viral DNA duplex synthesized in the cytosol of an infected cell by HIV-1 reverse transcriptase is not entirely clear. Studies of some viral systems suggest that this discontinuous structure is required for passage of the viral duplex DNA into the nucleus while there are evidence contrary to this observation. Studies in vitro indicate that human nuclear flap endonuclease and DNA ligase can remove the flap and seal the plus-strand discontinuity in HIV-1 DNA (Miller et al. 1995; Rausch and Le Grice 2004; Rumbaugh et al. 1998), although role of flap is not yet clear. Authored: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22

http://purl.obolibrary.org/obo/HINO_0026270

Reviewed: Hughes, SH, 2006-10-30 22:00:51

The fate of the discontinuous viral DNA duplex synthesized in the cytosol of an infected cell by HIV-1 reverse transcriptase is not entirely clear. Studies of some viral systems suggest that this discontinuous structure is required for passage of the viral duplex DNA into the nucleus while there are evidence contrary to this observation. Studies in vitro indicate that human nuclear flap endonuclease and DNA ligase can remove the flap and seal the plus-strand discontinuity in HIV-1 DNA (Miller et al. 1995; Rausch and Le Grice 2004; Rumbaugh et al. 1998), although role of flap is not yet clear.

Authored: Gopinathrao, G, D'Eustachio, P, 2006-05-18 20:10:22

Reactome, http://www.reactome.org

Pubmed7745750

Pubmed9786870

Pubmed15183342

http://purl.obolibrary.org/obo/HINO_0006005

http://purl.obolibrary.org/obo/HINO_0006008

Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA

HINO:0026270

Removal of plus-strand flap and gap closure complete synthesis of linear duplex viral DNA

GENE ONTOLOGYGO:0006278

ReactomeREACT_9036

Reactome Database ID Release 43182876

http://purl.obolibrary.org/obo/INO_0000040