The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Preferred Name	perphenazine
Synonyms	2-(4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl)ethanol 2-{4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethan-1-ol perphenazinum perphenazine perfenazina Perfenazine Trilafon gamma-(4-(beta-hydroxyethyl)piperazin-1-yl)propyl-2-chlorophenothiazine Chlorpiprazine Perphenazine 2-{4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethanol 2-chloro-10-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)phenothiazine C21H26ClN3OS 4-[3-(2-chlorophenothiazin-10-yl)propyl]-1-piperazineethanol Perphenazin 4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol
ID	http://purl.obolibrary.org/obo/CHEBI_8028
AHFScode	28:16.08.24
ATCCode	N05AB03
binds	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_0753 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_2804 http://purl.obolibrary.org/obo/dinto_0909 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1959 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_0465
blocks	http://purl.obolibrary.org/obo/dinto_2804 http://purl.obolibrary.org/obo/dinto_0909
CASRN	58-39-9
DBBrand	decentan thilatazin fentazin triphenot apo-perphenazine f-mon emesinal perphenan trilafon trilifan trifaron
DBname	perphenazine
DBSynonym	chlorperphenazine etaperazin perphenazin ethaperazine perfenazina perfenazine etaperazine pzc
Definition	A phenothiazine derivative having a chloro subsitituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the N-10 position.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000597 http://purl.obolibrary.org/obo/OAE_0000589 http://purl.obolibrary.org/obo/OAE_0000905 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000335 http://purl.obolibrary.org/obo/OAE_0000492 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000411 http://purl.obolibrary.org/obo/OAE_0001431 http://purl.obolibrary.org/obo/OAE_0001489 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0000333 http://purl.obolibrary.org/obo/OAE_0001069 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000920 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000539 http://purl.obolibrary.org/obo/OAE_0000454 http://purl.obolibrary.org/obo/OAE_0000632 http://purl.obolibrary.org/obo/OAE_0000642 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0001275 http://purl.obolibrary.org/obo/OAE_0001050 http://purl.obolibrary.org/obo/OAE_0001057 http://purl.obolibrary.org/obo/OAE_0001068 http://purl.obolibrary.org/obo/OAE_0000309 http://purl.obolibrary.org/obo/OAE_0000268 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000510 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0001106 http://purl.obolibrary.org/obo/OAE_0000542 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000606 http://purl.obolibrary.org/obo/OAE_0000866 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0000592 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000275 http://purl.obolibrary.org/obo/OAE_0001001 http://purl.obolibrary.org/obo/OAE_0000480 http://purl.obolibrary.org/obo/OAE_0000811
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2804 http://purl.obolibrary.org/obo/dinto_0909
has role	http://purl.obolibrary.org/obo/CHEBI_37930 http://purl.obolibrary.org/obo/CHEBI_50919 http://purl.obolibrary.org/obo/CHEBI_48561
InChI	InChI=1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2,4-7,16,26H,3,8-15H2
InChIKey	InChIKey=RGCVKNLCSQQDEP-UHFFFAOYSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_0753 http://purl.obolibrary.org/obo/dinto_2993
is metabolised by	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1959 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_0465
is substrate of	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1959 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_0465
label	perphenazine
may interact with	http://purl.obolibrary.org/obo/CHEBI_4469 http://purl.obolibrary.org/obo/dinto_DB00579 http://purl.obolibrary.org/obo/CHEBI_5000 http://purl.obolibrary.org/obo/CHEBI_5280 http://purl.obolibrary.org/obo/CHEBI_127342 http://purl.obolibrary.org/obo/CHEBI_42944 http://purl.obolibrary.org/obo/dinto_DB01579 http://purl.obolibrary.org/obo/dinto_DB00209 http://purl.obolibrary.org/obo/dinto_DB01578 http://purl.obolibrary.org/obo/dinto_DB00857 http://purl.obolibrary.org/obo/CHEBI_8874 http://purl.obolibrary.org/obo/CHEBI_4530 http://purl.obolibrary.org/obo/CHEBI_8067 http://purl.obolibrary.org/obo/CHEBI_53289 http://purl.obolibrary.org/obo/dinto_DB00342 http://purl.obolibrary.org/obo/CHEBI_3181 http://purl.obolibrary.org/obo/CHEBI_63598 http://purl.obolibrary.org/obo/dinto_DB00427 http://purl.obolibrary.org/obo/CHEBI_8080 http://purl.obolibrary.org/obo/dinto_DB00365 http://purl.obolibrary.org/obo/CHEBI_3720 http://purl.obolibrary.org/obo/dinto_DB00397 http://purl.obolibrary.org/obo/CHEBI_27796 http://purl.obolibrary.org/obo/dinto_DB01577 http://purl.obolibrary.org/obo/CHEBI_9467 http://purl.obolibrary.org/obo/dinto_DB00382 http://purl.obolibrary.org/obo/CHEBI_5557 http://purl.obolibrary.org/obo/CHEBI_439329 http://purl.obolibrary.org/obo/CHEBI_3044 http://purl.obolibrary.org/obo/dinto_DB01208 http://purl.obolibrary.org/obo/CHEBI_2679
modulates	http://purl.obolibrary.org/obo/dinto_2804 http://purl.obolibrary.org/obo/dinto_0909
prefixIRI	obo2:CHEBI_8028
prefLabel	perphenazine
SMILES	OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(Cl)C=C3)CC1 OCCN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc23)CC1
Synonym	2-(4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl)ethanol 2-{4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethan-1-ol perphenazinum perphenazine perfenazina Perfenazine Trilafon gamma-(4-(beta-hydroxyethyl)piperazin-1-yl)propyl-2-chlorophenothiazine Chlorpiprazine Perphenazine 2-{4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl}ethanol 2-chloro-10-(3-(4-(2-hydroxyethyl)piperazin-1-yl)propyl)phenothiazine C21H26ClN3OS 4-[3-(2-chlorophenothiazin-10-yl)propyl]-1-piperazineethanol Perphenazin 4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol
xref	KEGG COMPOUND:C07427 Patent:US2766235 PubChem Compound:4748 Wikipedia:http://en.wikipedia.org/wiki/Perphenazine Beilstein:54730 NIST Chemistry WebBook:58-39-9 DrugBank:DB00850 PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/tri1616.shtml National Drug Code Directory:0781-1046-01 ChemSpider:4586 ChEMBL:116505 Patent:US2860138 PubChem Substance:46507058 Guide To Pharmacology:209 KEGG DRUG:D00503 Drugs Product Database (DPD):726184 Drugs.com:http://www.drugs.com/cdi/perphenazine.html Wikipedia:Perphenazine IUPHAR:209 ChEBI:8028 RxList:http://www.rxlist.com/cgi/generic3/perphenazine.htm CiteXplore:1650428 PharmGKB:PA450882 CASRN:58-39-9
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_8028	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8028	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8028	FIDEO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8028	CCONT	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8028	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8028	COVID-19	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8028	GO-PLUS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8028	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8028	DDSS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8028	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8028	NIFSTD	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8028	ECTO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8028	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_8028	OBA	SAME_URI
http://purl.obolibrary.org/obo/OMIT_0011537	OMIT	LOOM
http://purl.obolibrary.org/obo/MESH_D010546	BERO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.494.741.593	RH-MESH	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#9538	OCHV	LOOM
http://purl.bioontology.org/ontology/SNMI/C-62A30	SNMI	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D010546	RH-MESH	LOOM
http://purl.obolibrary.org/obo/CHEBI_8028	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_8028	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_8028	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_8028	CCONT	LOOM
http://purl.obolibrary.org/obo/CHEBI_8028	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_8028	COVID-19	LOOM
http://purl.obolibrary.org/obo/CHEBI_8028	GO-PLUS	LOOM
http://purl.obolibrary.org/obo/CHEBI_8028	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_8028	DDSS	LOOM
http://purl.obolibrary.org/obo/CHEBI_8028	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_8028	NIFSTD	LOOM
http://purl.obolibrary.org/obo/CHEBI_8028	ECTO	LOOM
http://purl.obolibrary.org/obo/CHEBI_8028	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_8028	OBA	LOOM
http://purl.bioontology.org/ontology/VANDF/4017939	VANDF	LOOM
http://www.co-ode.org/ontologies/galen#Perphenazine	GALEN	LOOM
http://purl.bioontology.org/ontology/NDDF/001477	NDDF	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387229007	SNOMEDCT	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017400	PMAPP-PMO	LOOM
http://www.case.edu/EpSO.owl#Perphenazine	MEPO	LOOM
http://purl.obolibrary.org/obo/NCIT_C29355	BERO	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU012951	LOINC	LOOM
http://purl.bioontology.org/ontology/RXNORM/8076	RXNORM	LOOM
http://purl.bioontology.org/ontology/LNC/LP16242-7	LOINC	LOOM
http://purl.bioontology.org/ontology/ATC/N05AB03	ATC	LOOM
http://www.drugbank.ca/drugs/DB00850	FTC	LOOM
http://www.case.edu/EpilepsyOntology.owl#Perphenazine	EPSO	LOOM
http://www.semanticweb.org/ontologies/2011/1/Ontology1296772722296.owl#EPO_00000078	PDON	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29355	NCIT	LOOM
https://go.drugbank.com/drugs/DB00850	MDM	LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Perphenazine	APAONTO	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0031184	OCHV	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146289	NDFRT	LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass86ec426d_2c3f_49e5_8a91_86bd8660acac	WWECA	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.369.593	RH-MESH	LOOM
http://purl.bioontology.org/ontology/MESH/D010546	MESH	LOOM
http://purl.jp/bio/4/id/200906055869315090	IOBC	LOOM
http://stirdf.jst.go.jp/id/200907038300648379	IOBC	LOOM
http://purl.bioontology.org/ontology/RCD/x02LS	RCD	LOOM