The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	progesterone
Synonyms	Gelbkoerperhormon Agolutin (S)-4-Pregnene-3,20-dione Crinone luteohormone pregn-4-ene-3,20-dione (1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one (S)-Pregn-4-en-3,20-dione Akrolutin Progesterone PROGESTERONE Progesteron 4-Pregnene-3,20-dione (S)-Progesterone 17alpha-progesterone Delta(4)-pregnene-3,20-dione corpus luteum hormone C21H30O2
ID	http://purl.obolibrary.org/obo/CHEBI_17026
activates	http://purl.obolibrary.org/obo/dinto_3882 http://purl.obolibrary.org/obo/dinto_2827
AHFScode	68:32.00
altId	CHEBI:8453 CHEBI:439 CHEBI:26269 CHEBI:14896 CHEBI:18798 CHEBI:45786
ATCCode	G03DA03 G03AC06 L02AB02 G03DA04 G03DA02
binds	http://purl.obolibrary.org/obo/dinto_1974 http://purl.obolibrary.org/obo/dinto_1979 http://purl.obolibrary.org/obo/dinto_1972 http://purl.obolibrary.org/obo/dinto_1970 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_1559 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_3489 http://purl.obolibrary.org/obo/dinto_2828 http://purl.obolibrary.org/obo/dinto_1956 http://purl.obolibrary.org/obo/dinto_3324 http://purl.obolibrary.org/obo/dinto_3882 http://purl.obolibrary.org/obo/dinto_2827 http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0269 http://purl.obolibrary.org/obo/dinto_0285 http://purl.obolibrary.org/obo/dinto_2496 http://purl.obolibrary.org/obo/dinto_1221
blocks	http://purl.obolibrary.org/obo/dinto_3324
CASRN	57-83-0
DBBrand	progestosol prometrium cyclogesterin agolutin progestogel gestone prolidon utrogestan gesterol cyclogest prochieve colprosterone progestasert crinone progestol
DBname	progesterone
DBSynonym	progesteronum progesteronum [inn-latin] progesterona [inn-spanish] corpus luteum hormone
Definition	A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000496 http://purl.obolibrary.org/obo/OAE_0000395 http://purl.obolibrary.org/obo/OAE_0000449 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0001373 http://purl.obolibrary.org/obo/OAE_0000597 http://purl.obolibrary.org/obo/OAE_0000081 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000902 http://purl.obolibrary.org/obo/OAE_0001273 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000839 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000335 http://purl.obolibrary.org/obo/OAE_0000479 http://purl.obolibrary.org/obo/OAE_0001744 http://purl.obolibrary.org/obo/OAE_0000267 http://purl.obolibrary.org/obo/OAE_0000596 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000561 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000493 http://purl.obolibrary.org/obo/OAE_0000411 http://purl.obolibrary.org/obo/OAE_0000443 http://purl.obolibrary.org/obo/OAE_0001186 http://purl.obolibrary.org/obo/OAE_0000611 http://purl.obolibrary.org/obo/OAE_0001369 http://purl.obolibrary.org/obo/OAE_0000567 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0000249 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0000197 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0000250 http://purl.obolibrary.org/obo/OAE_0001025 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000050 http://purl.obolibrary.org/obo/OAE_0000426 http://purl.obolibrary.org/obo/OAE_0000476 http://purl.obolibrary.org/obo/OAE_0000945 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000103 http://purl.obolibrary.org/obo/OAE_0001055 http://purl.obolibrary.org/obo/OAE_0000454 http://purl.obolibrary.org/obo/OAE_0001026 http://purl.obolibrary.org/obo/OAE_0000632 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001357 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0001340 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000517 http://purl.obolibrary.org/obo/OAE_0000455 http://purl.obolibrary.org/obo/OAE_0001105 http://purl.obolibrary.org/obo/OAE_0000498 http://purl.obolibrary.org/obo/OAE_0000767 http://purl.obolibrary.org/obo/OAE_0000084 http://purl.obolibrary.org/obo/OAE_0001461 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000586 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0000643 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0001106 http://purl.obolibrary.org/obo/OAE_0000433 http://purl.obolibrary.org/obo/OAE_0000533 http://purl.obolibrary.org/obo/OAE_0000243 http://purl.obolibrary.org/obo/OAE_0000473 http://purl.obolibrary.org/obo/OAE_0000414 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0000469 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000525 http://purl.obolibrary.org/obo/OAE_0001164 http://purl.obolibrary.org/obo/OAE_0000968 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0002122 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0001403 http://purl.obolibrary.org/obo/OAE_0000536 http://purl.obolibrary.org/obo/OAE_0000898 http://purl.obolibrary.org/obo/OAE_0000647 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000185 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0000336 http://purl.obolibrary.org/obo/OAE_0001147 http://purl.obolibrary.org/obo/OAE_0001052 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0001030 http://purl.obolibrary.org/obo/OAE_0000873 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000881 http://purl.obolibrary.org/obo/OAE_0001263 http://purl.obolibrary.org/obo/OAE_0000462 http://purl.obolibrary.org/obo/OAE_0000466 http://purl.obolibrary.org/obo/OAE_0000358 http://purl.obolibrary.org/obo/OAE_0001309 http://purl.obolibrary.org/obo/OAE_0001170 http://purl.obolibrary.org/obo/OAE_0000766 http://purl.obolibrary.org/obo/OAE_0000500 http://purl.obolibrary.org/obo/OAE_0001458 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0000811 http://purl.obolibrary.org/obo/OAE_0000506 http://purl.obolibrary.org/obo/OAE_0000350
has pharmacological target	http://purl.obolibrary.org/obo/dinto_3324 http://purl.obolibrary.org/obo/dinto_3882 http://purl.obolibrary.org/obo/dinto_2827
has role	http://purl.obolibrary.org/obo/CHEBI_59826 http://purl.obolibrary.org/obo/CHEBI_70709 http://purl.obolibrary.org/obo/CHEBI_49323
InChI	InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
InChIKey	InChIKey=RJKFOVLPORLFTN-LEKSSAKUSA-N
induces	http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440
inhibits	http://purl.obolibrary.org/obo/dinto_1974 http://purl.obolibrary.org/obo/dinto_1979 http://purl.obolibrary.org/obo/dinto_1972 http://purl.obolibrary.org/obo/dinto_1970 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_1559 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_3489 http://purl.obolibrary.org/obo/dinto_2828 http://purl.obolibrary.org/obo/dinto_1956
is metabolised by	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0269 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_0285 http://purl.obolibrary.org/obo/dinto_2496 http://purl.obolibrary.org/obo/dinto_1956 http://purl.obolibrary.org/obo/dinto_1221
is substrate of	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0269 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_0285 http://purl.obolibrary.org/obo/dinto_2496 http://purl.obolibrary.org/obo/dinto_1956 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_1440
is transported by	http://purl.obolibrary.org/obo/dinto_1440
label	progesterone
may interact with	http://purl.obolibrary.org/obo/CHEBI_63632
modulates	http://purl.obolibrary.org/obo/dinto_3324 http://purl.obolibrary.org/obo/dinto_3882 http://purl.obolibrary.org/obo/dinto_2827
prefixIRI	obo2:CHEBI_17026
prefLabel	progesterone
SMILES	[H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C [H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@H](CC[C@@]21[H])C(C)=O
Synonym	Gelbkoerperhormon Agolutin (S)-4-Pregnene-3,20-dione Crinone luteohormone pregn-4-ene-3,20-dione (1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one (S)-Pregn-4-en-3,20-dione Akrolutin Progesterone PROGESTERONE Progesteron 4-Pregnene-3,20-dione (S)-Progesterone 17alpha-progesterone Delta(4)-pregnene-3,20-dione corpus luteum hormone C21H30O2
xref	Wikipedia:Progesterone ChEBI:17026 CASRN:57-83-0 KEGG COMPOUND:C00410 National Drug Code Directory:0591-3128-79 Wikipedia:http://en.wikipedia.org/wiki/Progesterone DrugBank:DB00396 Drugs.com:http://www.drugs.com/progesterone.html ChEMBL:112825 Beilstein:1915950 PubChem Compound:5994 PharmGKB:PA451123 PDBeChem:STR PDB:1CA PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/pro1670.shtml KEGG DRUG:D00066 NIST Chemistry WebBook:57-83-0 CiteXplore:9506942 Drugs Product Database (DPD):2240605 RxList:http://www.rxlist.com/cgi/generic/progesterone.htm Gmelin:708590 PubChem Substance:46508968 CiteXplore:10438974 ChemSpider:5773
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_17026	UBERON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_17026	CL	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_17026	OBA	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_17026	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_17026	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_17026	FIDEO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_17026	OBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_17026	INBANCIDO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_17026	CCONT	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_17026	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_17026	GO-PLUS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_17026	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_17026	HHEAR	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_17026	DDSS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_17026	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_17026	GSSO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_17026	CIDO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_17026	UPHENO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_17026	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_17026	NIFSTD	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_17026	ECTO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_17026	HINO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_17026	MCO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_17026	ZP	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_17026	UBERON	LOOM
http://purl.obolibrary.org/obo/CHEBI_17026	OBA	LOOM
http://purl.obolibrary.org/obo/XCO_0000381	XCO	LOOM
http://localhost/plosthes.2017-1#3833	PLOSTHES	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.808.745.745.654.829	RH-MESH	LOOM
http://purl.bioontology.org/ontology/VANDF/4017453	VANDF	LOOM
http://www.semanticweb.org/ontologies/epo.owl#Progesterone	EPO	LOOM
https://github.com/sap218/coid/blob/master/coid.owl#COID_00685	COID	LOOM
http://purl.bioontology.org/ontology/MESH/D011374	MESH	LOOM
http://purl.obolibrary.org/obo/OMIT_0012328	OMIT	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0033308	OCHV	LOOM
http://purl.jp/bio/4/id/200906052288489978	IOBC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D06.472.334.734.623	RH-MESH	LOOM
http://www.co-ode.org/ontologies/galen#Progesterone	GALEN	LOOM
http://purl.bioontology.org/ontology/CPT/84144	CPT	LOOM
http://purl.bioontology.org/ontology/CSP/2422-5382	CRISP	LOOM
http://purl.bioontology.org/ontology/NDDF/001290	NDDF	LOOM
http://purl.bioontology.org/ontology/MEDDRA/10063291	MEDDRA	LOOM
http://purl.obolibrary.org/obo/NCIT_C2297	BERO	LOOM
http://doe-generated-ontology.com/OntoAD#C0033308	ONTOAD	LOOM
http://www.radlex.org/RID/RID49952	RADLEX	LOOM
http://www.projecthalo.com/aura#Progesterone	AURA	LOOM
http://purl.obolibrary.org/obo/MESH_D011374	BERO	LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Progesterone	APAONTO	LOOM
http://purl.obolibrary.org/obo/IMR_0100034	HOIP	LOOM
http://purl.obolibrary.org/obo/IMR_0100034	TXPO	LOOM
http://purl.bioontology.org/ontology/RXNORM/8727	RXNORM	LOOM
http://www.pepathway.org/peo/1.2#progesterone	PE-O	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2297	NCIT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D011374	RH-MESH	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000145841	NDFRT	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/16683002	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/ATC/G03DA04	ATC	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003615	LOINC	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018726	PMAPP-PMO	LOOM
http://purl.obolibrary.org/obo/CHEBI_17026	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_17026	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_17026	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_17026	OBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_17026	INBANCIDO	LOOM
http://purl.obolibrary.org/obo/CHEBI_17026	CCONT	LOOM
http://purl.obolibrary.org/obo/CHEBI_17026	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_17026	GO-PLUS	LOOM
http://purl.obolibrary.org/obo/CHEBI_17026	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_17026	DDSS	LOOM
http://purl.obolibrary.org/obo/CHEBI_17026	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_17026	GSSO	LOOM
http://purl.obolibrary.org/obo/CHEBI_17026	CIDO	LOOM
http://purl.obolibrary.org/obo/CHEBI_17026	UPHENO	LOOM
http://purl.obolibrary.org/obo/CHEBI_17026	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_17026	NIFSTD	LOOM
http://purl.obolibrary.org/obo/CHEBI_17026	ECTO	LOOM
http://purl.obolibrary.org/obo/CHEBI_17026	HINO	LOOM
http://purl.obolibrary.org/obo/CHEBI_17026	MCO	LOOM
http://purl.obolibrary.org/obo/CHEBI_17026	ZP	LOOM
https://go.drugbank.com/drugs/DB00396	MDM	LOOM
http://purl.bioontology.org/ontology/LNC/LP14041-5	LOINC	LOOM
http://www.drugbank.ca/drugs/DB00396	FTC	LOOM
http://purl.bioontology.org/ontology/SNMI/F-B2450	SNMI	LOOM
http://stirdf.jst.go.jp/id/200907061312604042	IOBC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#10159	OCHV	LOOM
http://purl.bioontology.org/ontology/RCD/X80GL	RCD	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D06.472.334.851.687.750	RH-MESH	LOOM