Preferred Name |
keratinocyte |
|
Synonyms |
malpighian cell keratinized cell of epidermis |
|
Definitions |
Keratinocytes are reportedly CDw210a-negative, CDw210b-positive, CD281-positive, CD282-positive, CD285-positive, IL22Ra1-positive, Human keratinocytes are reportedly capable of secreting BD-2, BD-3, hCAP-18, CXCL1, CXCL5, CXCL8, elafin, MMP-3, NGAL, PDGF-A, S100A7, S100A8, and S100A9. Transcription factors: STAT3-positive. Skin cell, of the keratinized layer of epidermis: its characteristic intermediate filament protein is cytokeratin. An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell. |
|
ID |
http://purl.obolibrary.org/obo/CL_0000312 |
|
comment |
Keratinocytes are reportedly CDw210a-negative, CDw210b-positive, CD281-positive, CD282-positive, CD285-positive, IL22Ra1-positive, Human keratinocytes are reportedly capable of secreting BD-2, BD-3, hCAP-18, CXCL1, CXCL5, CXCL8, elafin, MMP-3, NGAL, PDGF-A, S100A7, S100A8, and S100A9. Transcription factors: STAT3-positive. Skin cell, of the keratinized layer of epidermis: its characteristic intermediate filament protein is cytokeratin. An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell. |
|
alternative term |
malpighian cell |
|
capable of |
http://purl.obolibrary.org/obo/GO_0090023 |
|
database_cross_reference |
CALOHA:TS-0500 BTO:0000667 FMA:62879 |
|
definition source |
BTO:0000667 CL:0000312 |
|
has exact synonym |
malpighian cell keratinized cell of epidermis |
|
has_alternative_id |
CL:0002185 |
|
has_obo_namespace |
cell |
|
imported from | ||
label |
keratinocyte |
|
part_of | ||
prefixIRI |
CL:0000312 |
|
prefLabel |
keratinocyte |
|
see also |
URI: http://www.ebi.ac.uk/cellline#keratinocyte EFO_URI: http://www.ebi.ac.uk/efo/EFO_0000560 |
|
term editor |
James Malone |
|
textual definition |
An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell. |
|
treeView | ||
subClassOf |
http://purl.obolibrary.org/obo/CL_0000000 http://purl.obolibrary.org/obo/BFO_0000040 |
This ontology integrates with OntoloBridge, allowing community users to suggest additions to the public ontology. Complete the template below to submit a term request directly to the ontology maintainer.
Term Label (required)
Suggested term name. If a term can be described with multiple synonyms, only list the preferred name here.
Term description (required)
A brief definition, description, or usage of your suggested term. Additional term synonyms may be listed in this section.
Superclass (required)
The parent term of the suggested term. The parent term should be an existing entry of the current ontology. The superclass can be selected directly from Bioportal's Classes tree viewer.
References (optional)
Provide evidence for the existence of the requested term such as Pubmed IDs of papers or links to other resources that describe the term.
Justification (optional)
Provide any additional information about the requested term here.