loading...| Preferred Name | hematopoietic stem cell | |
| Synonyms |
colony forming unit hematopoietic HSC blood forming stem cell hemopoietic stem cell |
|
| Definitions |
A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119. Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative. |
|
| ID |
http://purl.obolibrary.org/obo/CL_0000037 |
|
| comment |
Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative. |
|
| alternative label |
colony forming unit hematopoietic HSC blood forming stem cell hemopoietic stem cell |
|
| database_cross_reference |
MESH:D006412 BTO:0000725 CALOHA:TS-0448 VHOG:0001485 FMA:86475 |
|
| definition |
A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119. Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative. |
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| develops_from | ||
| has_exact_synonym |
blood forming stem cell hemopoietic stem cell |
|
| has_related_synonym |
colony forming unit hematopoietic HSC |
|
| in_subset |
http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim |
|
| label |
hematopoietic stem cell |
|
| prefixIRI |
CL:0000037 |
|
| prefLabel |
hematopoietic stem cell |
|
| present_in_taxon | ||
| textual definition |
A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119. |
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| treeView | ||
| subClassOf |
http://purl.obolibrary.org/obo/CL_0000723 |